CAJ | 학술논문

目的观察1％盐酸麻黄碱滴鼻液对高压氧治疗患者血压的影响，为高压氧治疗患者正确使用麻黄碱提供参考。方法将60例行高压氧治疗的患者按随机数字表法分为观察组和对照组各30例。进舱治疗前观察组滴1％盐酸麻黄碱滴鼻液（每侧鼻腔3滴），对照组不滴药，分别于治疗前、加压20 min、稳压吸氧25 min、稳压吸氧50 min、减压结束前、治疗结束后30 min测量患者坐位右侧上肢血压，观察两组血压变化，并进行统计学分析。结果加压20 min、稳压吸氧25 min、稳压吸氧50 min、减压结束前、治疗结束后30 min，观察组的收缩压和舒张压与对照组比较，差异均无统计学意义（ P＞0.05）。治疗过程两组血压均随时间呈先升高后下降趋势，与治疗前比较差异有统计学意义（ P＜0.05）。但组间与时点之间不存在交互作用，即滴药与不滴药对血压的影响是一致的。结论对血压正常的高压氧治疗患者，进舱前少量（每侧鼻腔3滴）滴1％盐酸麻黄碱滴鼻液对血压无影响。
목적관찰1％염산마황감적비액대고압양치료환자혈압적영향，위고압양치료환자정학사용마황감제공삼고。방법장60례행고압양치료적환자안수궤수자표법분위관찰조화대조조각30례。진창치료전관찰조적1％염산마황감적비액（매측비강3적），대조조불적약，분별우치료전、가압20 min、은압흡양25 min、은압흡양50 min、감압결속전、치료결속후30 min측량환자좌위우측상지혈압，관찰량조혈압변화，병진행통계학분석。결과가압20 min、은압흡양25 min、은압흡양50 min、감압결속전、치료결속후30 min，관찰조적수축압화서장압여대조조비교，차이균무통계학의의（ P＞0.05）。치료과정량조혈압균수시간정선승고후하강추세，여치료전비교차이유통계학의의（ P＜0.05）。단조간여시점지간불존재교호작용，즉적약여불적약대혈압적영향시일치적。결론대혈압정상적고압양치료환자，진창전소량（매측비강3적）적1％염산마황감적비액대혈압무영향。
Objective To provide a reference for proper use of ephedrine by observing impacts of nasal drop of 1%ephedrine hydrochloride on blood pressure of patients treated with hyperbaric oxygen ( HPO) .Methods Sixty HBO patients were randomly divided into two groups (30 cases for each), i.e.observed group and contrast group. Patients in observed group , before being sent into large medical hyperbaric oxygen tank , were put 1% ephedrine hydrochloride nasal drops three drops into bilateral nasal cavities while those in contrast group won ′t.Their blood pressure were measured at the right upper limb in different period of time , i.e.before HBO, at 20 min of pressuri-zing, at 25 min and 50 min of oxygen inhalation under stable pressure , before finishing of decompressing , at 30 min after HBO.Their blood pressure change were observed and statistical analysis was carried out .Results For systolic pressure and diastolic pressure , there was no significant difference between observed group and contrast group ( P>0.05 ) .The blood pressure of both groups increased first and then decreased during HBO , it had statistical signifi-cance comparing with prior treatment (P<0.05).But there was no interaction between groups and time-points, that showed , impacts on blood pressure treating with or without nasal drop were the same .Conclusion For those patients who is in normal blood pressure ,taking nasal drop of 1%ephedrine hydrochloride three drops into bilateral nasal cavi-ties before HBO does not affect blood pressure .