中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2014年
9期
803-805
,共3页
赵娟%张小勇%邓彩妹%沈锡林%潘伟
趙娟%張小勇%鄧綵妹%瀋錫林%潘偉
조연%장소용%산채매%침석림%반위
肱动脉%血流介导性舒张%可溶性细胞分化抗原40配体%急性冠状动脉综合征
肱動脈%血流介導性舒張%可溶性細胞分化抗原40配體%急性冠狀動脈綜閤徵
굉동맥%혈류개도성서장%가용성세포분화항원40배체%급성관상동맥종합정
Brachial artery%Flow mediated dilatation%soluble CD40 ligand(sCD40L)%Acute coro-nary syndrome(ACS)
目的：探讨超声检查肱动脉血流介导性舒张（ FMD ）和血清可溶性细胞分化抗原40配体（sCD40L）对急性冠状动脉综合征（ACS）的预测价值。方法随机入选39名健康志愿者、39例稳定性心绞痛患者（SA组）和79例急性冠状动脉综合征（ACS）患者。 ACS患者包括不稳定性心绞痛患者49例（UA组），急性心肌梗死患者30例（AMI组）。用超声检查肱动脉FMD，并用ELISA法检测血清sCD40L的含量。研究ACS患者肱动脉FMD和血清sCD40L的变化。用Pearson相关性分析ACS患者肱动脉FMD与血清sCD40L水平的关系。结果肱动脉 FMD 正常对照组（9.52±2.54）％， SA 组（5.35±1.24）％， UA 组（3.32±1.41）％，AMI组（3.26±1.32）％，ACS患者肱动脉FMD下调（P＜0.05）。血清sCD40L正常对照组（1.21±0.31）ng/ml，SA组（4.12±0.98）ng/ml，UA组（12.86±2.67）ng/ml，AMI组（13.95±2.83）ng/ml，ACS患者血清sCD40L升高（P＜0.05）。 ACS患者肱动脉FMD与血清sCD40L水平呈负相关，r＝-0.708，P＝0.000。结论超声发现肱动脉FMD下调，血清sCD40L升高，对ACS有预测价值。
目的：探討超聲檢查肱動脈血流介導性舒張（ FMD ）和血清可溶性細胞分化抗原40配體（sCD40L）對急性冠狀動脈綜閤徵（ACS）的預測價值。方法隨機入選39名健康誌願者、39例穩定性心絞痛患者（SA組）和79例急性冠狀動脈綜閤徵（ACS）患者。 ACS患者包括不穩定性心絞痛患者49例（UA組），急性心肌梗死患者30例（AMI組）。用超聲檢查肱動脈FMD，併用ELISA法檢測血清sCD40L的含量。研究ACS患者肱動脈FMD和血清sCD40L的變化。用Pearson相關性分析ACS患者肱動脈FMD與血清sCD40L水平的關繫。結果肱動脈 FMD 正常對照組（9.52±2.54）％， SA 組（5.35±1.24）％， UA 組（3.32±1.41）％，AMI組（3.26±1.32）％，ACS患者肱動脈FMD下調（P＜0.05）。血清sCD40L正常對照組（1.21±0.31）ng/ml，SA組（4.12±0.98）ng/ml，UA組（12.86±2.67）ng/ml，AMI組（13.95±2.83）ng/ml，ACS患者血清sCD40L升高（P＜0.05）。 ACS患者肱動脈FMD與血清sCD40L水平呈負相關，r＝-0.708，P＝0.000。結論超聲髮現肱動脈FMD下調，血清sCD40L升高，對ACS有預測價值。
목적：탐토초성검사굉동맥혈류개도성서장（ FMD ）화혈청가용성세포분화항원40배체（sCD40L）대급성관상동맥종합정（ACS）적예측개치。방법수궤입선39명건강지원자、39례은정성심교통환자（SA조）화79례급성관상동맥종합정（ACS）환자。 ACS환자포괄불은정성심교통환자49례（UA조），급성심기경사환자30례（AMI조）。용초성검사굉동맥FMD，병용ELISA법검측혈청sCD40L적함량。연구ACS환자굉동맥FMD화혈청sCD40L적변화。용Pearson상관성분석ACS환자굉동맥FMD여혈청sCD40L수평적관계。결과굉동맥 FMD 정상대조조（9.52±2.54）％， SA 조（5.35±1.24）％， UA 조（3.32±1.41）％，AMI조（3.26±1.32）％，ACS환자굉동맥FMD하조（P＜0.05）。혈청sCD40L정상대조조（1.21±0.31）ng/ml，SA조（4.12±0.98）ng/ml，UA조（12.86±2.67）ng/ml，AMI조（13.95±2.83）ng/ml，ACS환자혈청sCD40L승고（P＜0.05）。 ACS환자굉동맥FMD여혈청sCD40L수평정부상관，r＝-0.708，P＝0.000。결론초성발현굉동맥FMD하조，혈청sCD40L승고，대ACS유예측개치。
Objective To investigate the predictive value of ACS by brachial artery FMD and sCD 40L. Methods Thirty-nine healthy volunteers(control group), 39 patients with stable angina pectoris(SA group) and 79 patients with acute coronary syndrome (ACS),including 49 patients with unstable angina pectoris (UA group) and 30 patients with acute myocardial infarction (AMI group), were radomly selected.The patients with ACS were detected the brachial artery FMD by ultrasonic testing and the serum sCD 40L by ELISA.Relation of brachial artery FMD and serum sCD40L of ACS patients were analyzed by using Pearson correlation analysis .Results Compared with control group and SA goup , the brachial artery FMD decreased in UA group and AMI group ( 9.52 ±2.54 )%( control group) vs (5.35 ±1.24)%(SA group) vs (3.32 ±1.41)% (UA group) vs (3.26 ±1.32)%(AMI group), (P<0.05).Compared with control group and SA goup , the serum sCD40L increased in UA group and AMI group (1.21 ± 0.31)ng/ml(control group) vs (4.12 ±0.98)ng/ml(SA group) vs (12.86 ±2.67)ng/ml (UA group) vs (13.95 ± 2.83)ng/ml(AMI group), (P<0.05).Pearson correlation analysis indicted that the brachial artery FMD was nega-tively associated with the level of serum sCD40L in ACS patients (r=-0.708,P=0.000).Conclusion The down-regulation of brachial artery FMD by ultrasound findings and upregulation of serum sCD 40L have predictive value for the occurrence of ACS .
