中国病理生理杂志
中國病理生理雜誌
중국병리생리잡지
CHINESE JOURNAL OF PATHOPHYSIOLOGY
2014年
9期
1713-1716
,共4页
BRCC36蛋白%泛素化%DNA损伤修复%肿瘤%心脏疾病
BRCC36蛋白%汎素化%DNA損傷脩複%腫瘤%心髒疾病
BRCC36단백%범소화%DNA손상수복%종류%심장질병
BRCC36 protein%Ubiquitination%DNA damage repair%Neoplasms%Heart diseases
The protein of BRCC36 is a kind of enzyme specifically hydrolyzing K 63-linked poly-ubiquitin chain and widely found in a variety of eukaryotic cells .BRCC36 recognizes diverse substrate proteins , and participates in various kinds of pathophysiological responses such as DNA damage repair , cell signal transduction and cell cycle control .It plays an important role in the process of cancer , angiogenesis and cardiac injury .This review discusses the progress in the inves-tigation on BRCC36 protein to provide the necessary information for searching new therapeutic targets of many diseases .
