CAJ | 학술논문

人体肠道内的菌群参与了许多生理功能的维持和疾病的发生。作为大脑和胃肠道功能相互调节的重要桥梁，脑-肠轴功能的正常发挥是肠道菌群维持稳定的条件。脑-肠轴紊乱可激活肠黏膜免疫，对肠道菌群产生影响，使菌群结构发生改变。反之，肠道菌群结构改变亦会影响神经系统发育，导致脑-肠轴功能紊乱，其中迷走神经和血清代谢物质在脑-肠轴功能的调节中发挥重要作用。本文就肠道菌群与脑-肠轴功能相互影响的研究进展作一综述。
인체장도내적균군삼여료허다생리공능적유지화질병적발생。작위대뇌화위장도공능상호조절적중요교량，뇌-장축공능적정상발휘시장도균군유지은정적조건。뇌-장축문란가격활장점막면역，대장도균군산생영향，사균군결구발생개변。반지，장도균군결구개변역회영향신경계통발육，도치뇌-장축공능문란，기중미주신경화혈청대사물질재뇌-장축공능적조절중발휘중요작용。본문취장도균군여뇌-장축공능상호영향적연구진전작일종술。
Gut microbiota plays an important role in the maintenance of physiological function and genesis of some gut diseases. Brain-gut axis,as an important link between brain and gastrointestinal tract,is a requisite of gut microbiota stability. The dysfunction of brain-gut axis may lead to intestinal dysbiosis through activation of intestinal immune activity. Conversely,intestinal dysbiosis can influence nervous system development and may cause dysfunction of brain-gut axis,in which vagus nerve and metabolites in serum may be the critical factors. This article reviewed the advances in study on interaction between gut microbiota and brain-gut axis.