CAJ | 학술논문

目的：探讨颅脑损伤病人发生低钠血症的病因及防治措施。方法随机测定并统计分析60例单纯性颅脑损伤病人伤后1、7、14d 的血浆抗利尿激素（ADH）、血管紧张素Ⅱ（AngⅡ），及128例颅脑损伤并发低钠血症病人血浆中ADH、AngⅡ及24h尿钠。结果颅脑损伤后1、7、14d三组ADH、AngⅡ水平均明显高于对照组（ P ＜0．01）；颅脑损伤发生低钠血症的病人中，停用脱水药出入量平衡组血浆中ADH、AngⅡ与对照组比较差异有统计学意义（ P ＜0．01），与血浆钠浓度呈负相关；停用脱水药、出量大于入量组病人血浆中AD H、A ngⅡ明显降低，差异有统计学意义（ P ＜0．05），与血浆钠浓度呈正相关。结论 A ngⅡ在低钠血症的发生中起到了重要的作用。
목적：탐토로뇌손상병인발생저납혈증적병인급방치조시。방법수궤측정병통계분석60례단순성로뇌손상병인상후1、7、14d 적혈장항이뇨격소（ADH）、혈관긴장소Ⅱ（AngⅡ），급128례로뇌손상병발저납혈증병인혈장중ADH、AngⅡ급24h뇨납。결과로뇌손상후1、7、14d삼조ADH、AngⅡ수평균명현고우대조조（ P ＜0．01）；로뇌손상발생저납혈증적병인중，정용탈수약출입량평형조혈장중ADH、AngⅡ여대조조비교차이유통계학의의（ P ＜0．01），여혈장납농도정부상관；정용탈수약、출량대우입량조병인혈장중AD H、A ngⅡ명현강저，차이유통계학의의（ P ＜0．05），여혈장납농도정정상관。결론 A ngⅡ재저납혈증적발생중기도료중요적작용。
Objective To explore the causes and preventive measures of hyponatremia of patients with ponatremia were also measured .Results The ADH ,and angiotensin Ⅱ levels of the three groups injured on 1st day ,7thday and 14thday were significantly higher than those in the control group ( P<0 .01) .Among the craniocerebral injury patients with hyponatremia ,the difference of ADH and AngⅡ in plasma between the group of input equaling output after dehydrant being stopped and the control group was statistically significant( P <0 .01) ,which was negatively correlated with serum sodium concentration .The ADH and Angiotensin Ⅱ level of the group whose output volume was more than the input volume decreased signifi-cantly compared with the control group ,which was statistically significant and was positively correlated with serum sodium concentration .Conclusion Angiotensin Ⅱ plays an important role in the occurrence of hyponatremia .