山东医学高等专科学校学报
山東醫學高等專科學校學報
산동의학고등전과학교학보
JOURNAL OF SHANDONG MEDICAL COLLEGE
2014年
4期
261-263
,共3页
慢性肾脏病%非对称性二甲基精氨酸%高血压
慢性腎髒病%非對稱性二甲基精氨痠%高血壓
만성신장병%비대칭성이갑기정안산%고혈압
Chronic Kidney Disease%Asymmetric dimethylarginine%Hypertension
目的：探讨慢性肾脏病患者（CKD ）血清非对称性二甲基精氨酸（ADM A ）浓度与血压之间的相关性。方法选取30名慢性肾脏病患者作为研究对象，健康对照28名；应用高效液相色谱-质谱联用法测定研究对象血清与尿液ADM A浓度。结果慢性肾脏病患者血清ADM A 浓度明显高于健康对照组，而尿液ADM A浓度明显低于对照组，差异均有统计学意义（ P ＜0．01）；慢性肾脏病患者血清ADM A浓度与收缩压、舒张压呈明显正相关（分别为r＝0．724，P＜0．0l；r＝0．637， P ＜0．01）。结论慢性肾脏病患者血清ADM A 浓度较正常人群明显升高，且与血压水平呈正相关。
目的：探討慢性腎髒病患者（CKD ）血清非對稱性二甲基精氨痠（ADM A ）濃度與血壓之間的相關性。方法選取30名慢性腎髒病患者作為研究對象，健康對照28名；應用高效液相色譜-質譜聯用法測定研究對象血清與尿液ADM A濃度。結果慢性腎髒病患者血清ADM A 濃度明顯高于健康對照組，而尿液ADM A濃度明顯低于對照組，差異均有統計學意義（ P ＜0．01）；慢性腎髒病患者血清ADM A濃度與收縮壓、舒張壓呈明顯正相關（分彆為r＝0．724，P＜0．0l；r＝0．637， P ＜0．01）。結論慢性腎髒病患者血清ADM A 濃度較正常人群明顯升高，且與血壓水平呈正相關。
목적：탐토만성신장병환자（CKD ）혈청비대칭성이갑기정안산（ADM A ）농도여혈압지간적상관성。방법선취30명만성신장병환자작위연구대상，건강대조28명；응용고효액상색보-질보련용법측정연구대상혈청여뇨액ADM A농도。결과만성신장병환자혈청ADM A 농도명현고우건강대조조，이뇨액ADM A농도명현저우대조조，차이균유통계학의의（ P ＜0．01）；만성신장병환자혈청ADM A농도여수축압、서장압정명현정상관（분별위r＝0．724，P＜0．0l；r＝0．637， P ＜0．01）。결론만성신장병환자혈청ADM A 농도교정상인군명현승고，차여혈압수평정정상관。
Objective To investigate the relationship between serum asymmetric dimethylarginine (AD-MA ) concentration level and blood pressure in patients with chronic kidney disease (CKD) .Methods A to-tal of 30CKD patients were selected as subjects .The levels of ADMA in the serum and urine of 30 CKD patients were determined by using high performance liquid chromatography-mass spectrometry (HPLC-MS) .Results The serum level of ADMA was higher ,but the level of urinary ADMA was lower in the pa-tients with CKD than those in the controls ( P <0 .01) .The serum ADMA level was positively related to the levels of systolic blood pressure and diastolic blood pressure ,( r =0 .724 ,P<0 .0l;r =0 .637 ,P<0 . 01) .Conclusion n The serum level of ADMA in the patients with CKD is higher than that in the normal population .T he serum ADM A level is positively related to the level of blood pressure .
