CAJ | 학술논문

三氟甲基化合物和茚酮化合物具有许多独特的理化性质和生物活性，在农药、医药、染料和功能材料领域应用广泛。以对三氟甲基苯甲醛为原料，经Knoevenagel缩合、分子内Friedel-Crafts酰化、环氧化物不对称开环等步骤，经9步反应以总收率22%得目标化合物5-三氟甲基-2-茚酮，其结构经1 H NMR、13 C NMR、DEPT、HR-ESI-MS和元素分析表征。
삼불갑기화합물화인동화합물구유허다독특적이화성질화생물활성，재농약、의약、염료화공능재료영역응용엄범。이대삼불갑기분갑철위원료，경Knoevenagel축합、분자내Friedel-Crafts선화、배양화물불대칭개배등보취，경9보반응이총수솔22%득목표화합물5-삼불갑기-2-인동，기결구경1 H NMR、13 C NMR、DEPT、HR-ESI-MS화원소분석표정。
Applications of compounds containing trifluoromethyl and indanone in the fields of pesticide,medicine,dyes and function-al materials were wide,because of their unique properties of physics and chemistry as well as excellent bioactivities. Herein the 5-trifluoromethyl-2-indanone was synthesized starting from 4-trifluoromethyl benzaldehyde with the Knoevenagel condensation,Friedel-Crafts acylation and asymmetric ring opening of epoxide as the key steps through nine steps in 22%overall yields,and the product was characterized by 1 H NMR,13 C NMR,HR-ESI-MS,element analysis and found to be in good agreement with its structure.