CAJ | 학술논문

目的探讨氨磺必利对男性精神分裂症患者性功能与催乳素的影响。方法将60例精神分裂症患者随机分为氨磺必利组30例和阿立哌唑组30例，治疗8周，分别于治疗前，治疗后第8周采用亚利桑那性体验量表( ASEX)自评，同时评定阳性与阴性症状量表( PANSS)及治疗时出现的症状量表( TESS)，检查血清催乳素。结果治疗第8周末，氨磺必利组ASEX总分及性冲动因子分、性唤起因子分、性高潮满意度因子分、血浆催乳素均较治疗前升高(P<0.05)，阿立哌唑组无明显变化( P>0.05)；两组患者疗效相当，副反应均较轻；血浆催乳素与第8周末全体患者与氨磺必利组患者ASEX总分呈显著正相关( P<0.05)，氨磺必利剂量与性功能和催乳素水平无显著相关性( P>0.05)。结论氨磺必利对男性精神分裂症患者性功能及催乳素影响较大。
목적탐토안광필리대남성정신분렬증환자성공능여최유소적영향。방법장60례정신분렬증환자수궤분위안광필리조30례화아립고서조30례，치료8주，분별우치료전，치료후제8주채용아리상나성체험량표( ASEX)자평，동시평정양성여음성증상량표( PANSS)급치료시출현적증상량표( TESS)，검사혈청최유소。결과치료제8주말，안광필리조ASEX총분급성충동인자분、성환기인자분、성고조만의도인자분、혈장최유소균교치료전승고(P<0.05)，아립고서조무명현변화( P>0.05)；량조환자료효상당，부반응균교경；혈장최유소여제8주말전체환자여안광필리조환자ASEX총분정현저정상관( P<0.05)，안광필리제량여성공능화최유소수평무현저상관성( P>0.05)。결론안광필리대남성정신분렬증환자성공능급최유소영향교대。
Objective To investigate the influence of amisulpride treatment on sexual function and prolactin secre-tion in male schizophrenia. Methods 60 patients of schizophrenia were randomly divided into two groups, each of which received either amisulpride (30 cases) or aripiprazole(30 cases) treatment for 8 weeks. The Arizona sexual experience scale ( ASEX ) was self-evaluated before and after 8 weeks treatment , respectively . The positive and negative symptom scales ( PANSS ) were used to evaluate treatment efficacy while side effects were assessed by treatment emergent symptom scale ( TESS) and prolactin levels were measured in the same time. Results After 8 weeks treatment, ASEX scores, sex drive scores, sexually aroused scores, orgasms satisfying scores, prolactin lev-els were significantly higher than before in the patients receiving amisulpride. No significant difference was in arip-iprozole group. The therapeutic effects were nearly equivalent; and the side effects of both were weak. Prolactin levels had significantly positive correlation with ASEX scores within the whole patients and amisulpride group after 8 weeks treatment. No significant correlation was detected between amisulpride dosage and either sex function or pro-lactin levels . Conclusion Amisulpride has stronger effects in sexual function and serum prolactin of male schizo-phrenia patients.