中国伤残医学
中國傷殘醫學
중국상잔의학
CHINESE JOURNAL OF TRAUMA AND DISABILITY MEDICINE
2014年
19期
20-21
,共2页
血管性痴呆%丁苯酞%血管内皮生长因子
血管性癡呆%丁苯酞%血管內皮生長因子
혈관성치태%정분태%혈관내피생장인자
Vascular dementia%Butylphthalide%VEGF
目的:观察丁苯酞软胶囊治疗血管性痴呆患者的临床疗效及对血管内皮生长因子( VEGF)的影响。方法:将94例血管性痴呆患者随机分为丁苯酞软胶囊治疗组和对照组,对所有患者治疗前后采用MMSE、ADL评分进行认知能力及日常生活能力评估。并检测2组治疗前后VEGF的变化。结果:治疗组治疗后MMSE、ADL评分均优于对照组,治疗组治疗后总有效率明显高于对照组,治疗后治疗组VEGF水平明显升高,2组均有显著差异(p<0.05)。结论:丁苯酞软胶囊能够显著改善血管性痴呆患者的症状,其作用机制可能与提高VEGF水平有关。
目的:觀察丁苯酞軟膠囊治療血管性癡呆患者的臨床療效及對血管內皮生長因子( VEGF)的影響。方法:將94例血管性癡呆患者隨機分為丁苯酞軟膠囊治療組和對照組,對所有患者治療前後採用MMSE、ADL評分進行認知能力及日常生活能力評估。併檢測2組治療前後VEGF的變化。結果:治療組治療後MMSE、ADL評分均優于對照組,治療組治療後總有效率明顯高于對照組,治療後治療組VEGF水平明顯升高,2組均有顯著差異(p<0.05)。結論:丁苯酞軟膠囊能夠顯著改善血管性癡呆患者的癥狀,其作用機製可能與提高VEGF水平有關。
목적:관찰정분태연효낭치료혈관성치태환자적림상료효급대혈관내피생장인자( VEGF)적영향。방법:장94례혈관성치태환자수궤분위정분태연효낭치료조화대조조,대소유환자치료전후채용MMSE、ADL평분진행인지능력급일상생활능력평고。병검측2조치료전후VEGF적변화。결과:치료조치료후MMSE、ADL평분균우우대조조,치료조치료후총유효솔명현고우대조조,치료후치료조VEGF수평명현승고,2조균유현저차이(p<0.05)。결론:정분태연효낭능구현저개선혈관성치태환자적증상,기작용궤제가능여제고VEGF수평유관。
Objective:To study the clinical efficacy and the effect on the value of serum VEGF level of butylphthalide in the treatment of vascular dementia .Methods:94 patients with vascular dementia were randomly divided into butylphthalide treatment group and control group.MMSE scales and ADL scales were used to assess cognitive dysfunction ,daily living activities .The level of VEGF were measured in all patients before and after treatment .Results:MMSE scales and ADL scales in the butylphthalide group were better than that in the control group(p<0.05), the effective rate and the level of VEGF in the butylphthalide group was higher than that in the control group (p<0.05).Conclusion:Butylphthalide can effective improve cognitive dysfunction and daily living activities .Furthermore, butylphthalide can improve the level of VEGF .