CAJ | 학술논문

铁调素是维持机体铁稳态的重要调节因子，可以下调血清铁水平。慢性肾脏病患者体内会造成铁调素不同程度蓄积，引起铁代谢障碍，导致或加重患者的贫血或引起促红细胞生成素的低反应性。通过降低铁调素水平或抑制铁调素信号传导通路，可能会释放铁储备，实现纠正贫血的效果。然而，关于抗铁调素治疗的临床安全性问题尚需进一步的研究。
철조소시유지궤체철은태적중요조절인자，가이하조혈청철수평。만성신장병환자체내회조성철조소불동정도축적，인기철대사장애，도치혹가중환자적빈혈혹인기촉홍세포생성소적저반응성。통과강저철조소수평혹억제철조소신호전도통로，가능회석방철저비，실현규정빈혈적효과。연이，관우항철조소치료적림상안전성문제상수진일보적연구。
Hepcidinisanimportantregulatorforironhomeostasis,whichcandecreasetheserumironlevel.Serum hepcidin levels will increase in patients with chronic kidney diseases,which may contribute to the development and severity of a-nemia,and resistance to erythropoietin. Anemia may be corrected by releasing the iron reserve through reducing hepcidin levels or suppressing hepcidin signaling pathway in patients with chronic kidney diseases. However,clinical safety of anti-hepcidin thera-py still requires further investigation.