CAJ | 학술논문

流行病学研究表明，微生物和微生物组分对过敏性疾病及慢性炎性疾病有保护作用。在生命早期使用益生元、益生菌，可以通过早期的肠道菌群定植形成稳定内环境和免疫耐受，以及一级预防减少过敏性疾病及慢性炎性疾病的发生；应用细菌溶解物可以预防哮喘和感染性疾病，减少反复感染的几率。本文对益生元、益生菌和细菌溶解物对婴幼儿免疫功能的作用进行综述，探讨目前研究存在的问题，并对未来的临床研究提出改进设想和方向。
류행병학연구표명，미생물화미생물조분대과민성질병급만성염성질병유보호작용。재생명조기사용익생원、익생균，가이통과조기적장도균군정식형성은정내배경화면역내수，이급일급예방감소과민성질병급만성염성질병적발생；응용세균용해물가이예방효천화감염성질병，감소반복감염적궤솔。본문대익생원、익생균화세균용해물대영유인면역공능적작용진행종술，탐토목전연구존재적문제，병대미래적림상연구제출개진설상화방향。
Epidemiologicalstudieshaveshownthatmicroorganismsandmicrobialcomponentshaveprotectiveeffecta-gainst allergic diseases and chronic inflammatory diseases. Most results show that using prebiotics,probiotics in early life can de-velop a stable internal environment and immune tolerance with gut microbiological colonization,and reduce the incidence of aller-gic and inflammatory diseases by primary prevention as well;while using bacterial lysates in early life can prevent the occurrence of asthma and infectious diseases,and reduce the chances of recurrent infection. This article aims to review the effects of probiot-ics,prebiotics and bacterial lysate on infants'immunity,and discuss the existing problems in current,so as to put forward impro-ving suggestions and directions for future clinical research.