CAJ | 학술논문

目的：探讨江苏人群主要组织相容性复合体-Ⅰ类链相关基因A （M IC A ）基因多态性分布情况及其与乙型肝炎源性肝癌的关系。方法乙型肝炎源性肝癌组161例患者，健康对照组162例健康体检者，应用聚合酶链反应测序方法进行基因分型。比较各基因型等位基因频率分布及与乙型肝炎源性肝癌的关系。结果受试者携带GG基因型比携带AA基因型患乙型肝炎源性肝癌的风险高[比值比（OR）：1．860，95％置信区间（95％ CI）：1．009～3．428，P＝0．020]，或至少携带1个G等位基因的受试者比携带 A 等位基因的受试者更易患乙型肝炎源性肝癌（OR：1．412，95％ CI：1．030～1．936，P＝0．046）。GG基因型患者血清MICA水平[（89．1±41．7）pg／mL]明显高于AA基因型[（18．2±9．5）pg／mL]和 AG 基因型[（35．8±17．4）pg／mL]。结论江苏人群 MICA 基因多态性（rs2596542）与乙型肝炎源性肝癌相关。
목적：탐토강소인군주요조직상용성복합체-Ⅰ류련상관기인A （M IC A ）기인다태성분포정황급기여을형간염원성간암적관계。방법을형간염원성간암조161례환자，건강대조조162례건강체검자，응용취합매련반응측서방법진행기인분형。비교각기인형등위기인빈솔분포급여을형간염원성간암적관계。결과수시자휴대GG기인형비휴대AA기인형환을형간염원성간암적풍험고[비치비（OR）：1．860，95％치신구간（95％ CI）：1．009～3．428，P＝0．020]，혹지소휴대1개G등위기인적수시자비휴대 A 등위기인적수시자경역환을형간염원성간암（OR：1．412，95％ CI：1．030～1．936，P＝0．046）。GG기인형환자혈청MICA수평[（89．1±41．7）pg／mL]명현고우AA기인형[（18．2±9．5）pg／mL]화 AG 기인형[（35．8±17．4）pg／mL]。결론강소인군 MICA 기인다태성（rs2596542）여을형간염원성간암상관。
Objective To investigate the distribution of MICA polymorphism in Han population in Jiangsu ,the correlation between MICA polymorphism and HBV-related hepatocellular carcinoma (HCC) .Methods One hundred patients with HBV-related HCC were selected into HCC group (n=161) ,162 healthy people were divided into con-trol group .Genotyping was conducted by using polymerase chain reaction-sequencing ,allele frequency distribution and its correlation with HBV-related hepatocellular carcinoma were compared between the two groups .Results Compared with objectives with AA homozygote genotype ,objects with GG genotype had more risk with HCC (OR:1 .860 ,95% CI:1 .009-3 .428 ,P=0 .020) .Objects at least carrying one G allele had more risk with HCC than objec-tives carrying A allele(OR:1 .412 ,95% CI:1 .030-1 .936 ,P=0 .046) .In HCC patients ,the GG genotype was associ-ated with a significant higher serum levels of MICA compared to the AG or AA genotype .Conclusion The results suggested that MICA polymorphism was significant associated with HBV-related hepatocellular carcinoma among Han population in Jiangsu .