CAJ | 학술논문

目的：观察卡托普利联合低分子肝素治疗肾病综合征的临床效果。方法选择本院收治的68例肾病综合征患者为研究对象。对照组30例患者，给予常规治疗28 d；观察组38例患者，在常规治疗的基础上给予卡托普利联合低分子肝素治疗28 d。观察并比较两组患者治疗前后胆固醇、三酰甘油、肌酐、清蛋白、尿蛋白、全血高切黏度、全血低切黏度、血浆黏度、血浆纤维蛋白原、血细胞比容等指标变化情况。结果观察组治疗总有效率达92．1％，明显高于对照组的83．3％，比较差异有统计学意义（ P＜0．05）。治疗28 d后，观察组胆固醇、三酰甘油、尿蛋白、全血黏度、血浆黏度、血浆纤维蛋白原、血细胞比容等指标明显低于对照组，比较差异有统计学意义（P＜0．05）。结论在常规治疗的基础上加用卡托普利联合低分子肝素治疗肾病综合征，可明显提高疗效，改善肾功能及高凝状态，值得临床推广应用。
목적：관찰잡탁보리연합저분자간소치료신병종합정적림상효과。방법선택본원수치적68례신병종합정환자위연구대상。대조조30례환자，급여상규치료28 d；관찰조38례환자，재상규치료적기출상급여잡탁보리연합저분자간소치료28 d。관찰병비교량조환자치료전후담고순、삼선감유、기항、청단백、뇨단백、전혈고절점도、전혈저절점도、혈장점도、혈장섬유단백원、혈세포비용등지표변화정황。결과관찰조치료총유효솔체92．1％，명현고우대조조적83．3％，비교차이유통계학의의（ P＜0．05）。치료28 d후，관찰조담고순、삼선감유、뇨단백、전혈점도、혈장점도、혈장섬유단백원、혈세포비용등지표명현저우대조조，비교차이유통계학의의（P＜0．05）。결론재상규치료적기출상가용잡탁보리연합저분자간소치료신병종합정，가명현제고료효，개선신공능급고응상태，치득림상추엄응용。
Objective To observe the treatment effect of captopril combined low molecular heparin in nephrot-ic syndrome .Methods Sixty and eight patients with nephrotic syndrome were collected from Chongqing cancer hos-pital ,which were randomly divided into control group and observation group .Conventional treatment were used in the control group ,captopril combined with low molecular heparin were added in the observation group .cholesterol , triglyceride ,urine protein ,whole blood viscosity ,hematocrit ,fibrinogen ,hematocrit of pigeon before and after treat-ment were compared .Results Total effective rate of observation group was 92 .1% ,which was significantly higher than the control group′s 83 .3% ,the difference was statistically significant (P<0 .05) .The observation group′s cho-lesterol ,triglyceride ,urine protein ,whole blood viscosity ,hematocrit ,fibrinogen ,hematocrit of pigeon were significant lower than those of the control group (P<0 .05) .Conclusion On the basis of conventional treatment ,captopril and low molecular heparin could significantly improve curative effect ,renal function and high coagulation state on pa-tients with nephrotic syndrome .