CAJ | 학술논문

目的：探讨血清人附睾蛋白4（HE4）和糖类抗原125（CA125）两种肿瘤标志物在卵巢癌诊断中的应用价值。方法采用罗氏Cobase 601全自动电化学发光免疫分析仪对574例妇科附件肿块或术后复查患者进行血清HE4和CA125检测，并结合病理诊断将患者分为卵巢癌组18例，卵巢癌术后组12例，良性组544例。比较3组患者血清 HE4和CA125水平的差异，并运用受试者工作特征曲线（ROC曲线）分析HE4和CA25在卵巢癌诊断中的性能。结果卵巢癌组 HE4和CA125水平中位数分别为262．0 pmol／L、373．3 U／mL ，良性组为48．0 pmol／L、17．2 U／mL ，卵巢癌术后组为49．2 pmol／L、18．4 U／mL。HE4对卵巢癌诊断的最佳界值为115．7 pmol／L ，灵敏度为94．4％，特异性为96．9％，ROC曲线下面积为0．984；CA125的诊断灵敏度为83．3％，特异性为75．4％，ROC曲线下面积为0．911。结论 HE4检测对卵巢癌诊断的临床效能优于 CA125检测，可单独用于卵巢癌的辅助诊断。
목적：탐토혈청인부고단백4（HE4）화당류항원125（CA125）량충종류표지물재란소암진단중적응용개치。방법채용라씨Cobase 601전자동전화학발광면역분석의대574례부과부건종괴혹술후복사환자진행혈청HE4화CA125검측，병결합병리진단장환자분위란소암조18례，란소암술후조12례，량성조544례。비교3조환자혈청 HE4화CA125수평적차이，병운용수시자공작특정곡선（ROC곡선）분석HE4화CA25재란소암진단중적성능。결과란소암조 HE4화CA125수평중위수분별위262．0 pmol／L、373．3 U／mL ，량성조위48．0 pmol／L、17．2 U／mL ，란소암술후조위49．2 pmol／L、18．4 U／mL。HE4대란소암진단적최가계치위115．7 pmol／L ，령민도위94．4％，특이성위96．9％，ROC곡선하면적위0．984；CA125적진단령민도위83．3％，특이성위75．4％，ROC곡선하면적위0．911。결론 HE4검측대란소암진단적림상효능우우 CA125검측，가단독용우란소암적보조진단。
Objective To investigate the application value of human sapiens epididymis specific protein 4 (HE4) and carbohydrate antigen 125(CA125)in the diagnosis of ovarian cancer .Methods The serum levels of HE4 and CA125 in 574 adnexal mass patients or post-operation patients were detected by automatic electrochemical lumi-nescence immunity analyzer of Roche Cobase 601 .According to clinical and pathological diagnosis ,the 574 female pa-tients were divided into three groups ,18 patients in ovarian cancer group ,12 patients accepted ovarian cancer opera-tion in post-operation group ,544 patients with benign tumor in benign disease group .The differences on the levels of HE4 and CA125 in the three groups were compared ,and the performances of HE4 and CA125 in the diagnosis of o-varian cancer were determined by the receiver operating characteristic (ROC) curve .Results The median levels of HE4 and CA125 in the ovarian cancer group ,benign disease group and post-operation group were 262 .0 pmol/L and 373 .3 U/mL ,48 .0 pmol/L and 17 .2 U/mL ,49 .2 pmol/L and 18 .4 U/mL respectively .The upper limit of normal for HE4 in diagnosing for ovarian cancer was 115 .7 pmol/L ,and the sensitivity was 94 .4% ,the specificity was 96 .94% ,the area under the ROC curve was 0 .984 .The sensitivity ,specificity and area under the ROC curve of CA125 were 83 .3% ,75 .4% and 0 .911 respectively .Conclusion The detection of HE4 is superior to the detection of CA125 ,and could be used in the assist diagnosis of ovarian cancer separately .