CAJ | 학술논문

目的：分析不同剂量盐酸戊乙奎醚对患者术后认知功能的影响程度。方法将200例外科手术患者随机分为A、B、C、D、E组，每组各40例患者，麻醉前盐酸戊乙奎醚注射液的注射剂量分别为0．020、0．017、0．014、0．011、0．008 mg／kg。比较各组患者术前和术后3 d简单智力状态检查表（MMSE）评分，术后认知功能障碍与谵妄发生率，以及药物注射后的口干情况。结果术后3 d MMSE评分由高到低依次为 E、D、C、B、A组，其中C、D、E组术后3 d与术前比较差异无统计学意义（P＞0．05）。术后认知功能障碍与谵妄的发生率由高到低依次为A、B、C、D、E组。盐酸戊乙奎醚注射后10、20、30 min ，口干评分由高到低依次为A、B、C、D、E组，且随着时间的延长，患者的口干程度逐渐增高。结论在一定剂量范围内使用盐酸戊乙奎醚，可以发挥良好的效果，有助于降低术后认知功能障碍的发生率。
목적：분석불동제량염산무을규미대환자술후인지공능적영향정도。방법장200예외과수술환자수궤분위A、B、C、D、E조，매조각40례환자，마취전염산무을규미주사액적주사제량분별위0．020、0．017、0．014、0．011、0．008 mg／kg。비교각조환자술전화술후3 d간단지력상태검사표（MMSE）평분，술후인지공능장애여섬망발생솔，이급약물주사후적구간정황。결과술후3 d MMSE평분유고도저의차위 E、D、C、B、A조，기중C、D、E조술후3 d여술전비교차이무통계학의의（P＞0．05）。술후인지공능장애여섬망적발생솔유고도저의차위A、B、C、D、E조。염산무을규미주사후10、20、30 min ，구간평분유고도저의차위A、B、C、D、E조，차수착시간적연장，환자적구간정도축점증고。결론재일정제량범위내사용염산무을규미，가이발휘량호적효과，유조우강저술후인지공능장애적발생솔。
Objective To analyze the influence of different dosage of penehyclidine hydrochloride on postoper-ative cognitive function .Methods A total of 200 patients receiving operation treatment were enrolled and randomly divided into A ,B ,C ,D and E group (200 cases for each group) ,receiving injection of penehyclidine hydrochloride at dosage of 0 .020 ,0 .017 ,0 .014 ,0 .011 and 0 .008 mg/kg .Preoperative and tree-day postoperative Mini Mental State Examination (MMSE) scores ,incidence rate of postoperative cognitive dysfunction and delirium ,and thirst condition after injection were compared .Results Three-day postoperative MMSE scores decreased in the order of E ,D ,C ,B and A group .,and in C ,D and E group ,the differences of MMSE scores detected preoperatively and three-day post-operatively were not significant (P>0 .05) .Incidence rates of postoperative cognitive dysfunction and delirium de-creased in the order of A ,B ,C ,D and E group .10 ,20 and 30 min after injection of penehyclidine hydrochloride ,xeros-tomia score decreased in the order of A ,B ,C ,D and E group ,and with prolongation of time ,the degree of xerostomia gradually increased in each group .Conclusion Application of penehyclidine hydrochloride at dosage of a certain range could reduce the incidence rate of postoperative cognitive dysfunction .