检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
18期
2532-2533,2536
,共3页
人附睾蛋白4%糖链抗原125%上皮性癌
人附睪蛋白4%糖鏈抗原125%上皮性癌
인부고단백4%당련항원125%상피성암
human epididymis protein 4%carbohydrate antigen 125%epithelial carcinoma
目的：探讨人附睾蛋白4（HE4）和糖链抗原125（CA125）联合检测在女性上皮性癌诊断和鉴别诊断中的应用价值。方法于2011年3月至2012年4月，对58例上皮性癌和64例良性病变女性患者进行血清CA125和HE4检测，分析CA125和HE4在良、恶性病变患者中的表达水平及二者联合检测的诊断效能。结果上皮性卵巢癌和其他上皮性癌患者血清HE4、CA125水平均高于良性病变患者（P＜0．05），上皮性卵巢癌和其他上皮性癌患者血清 HE4水平比较差异无统计学意义（P＞0．05）。HE4、CA125单项检测的诊断灵敏度分别为46．6％和60．3％，联合检测诊断灵敏度为70．7％，较单项检测明显提高（ P＜0．05）。以良性疾病患者为参照人群，H E4、CA125单项检测及二者联合检测的受试者工作特征曲线下面积分别为0．783、0．679和0．791。血清 HE4临界值设为107．145 pmol／L时，诊断指数最大，灵敏度和特异度分别为69．0％和78．1％。结论 HE4是灵敏度较高的上皮性癌血清标志物，与CA125联合检测有助于提高肿瘤的检出率和诊断效能，有良好的应用前景。
目的：探討人附睪蛋白4（HE4）和糖鏈抗原125（CA125）聯閤檢測在女性上皮性癌診斷和鑒彆診斷中的應用價值。方法于2011年3月至2012年4月，對58例上皮性癌和64例良性病變女性患者進行血清CA125和HE4檢測，分析CA125和HE4在良、噁性病變患者中的錶達水平及二者聯閤檢測的診斷效能。結果上皮性卵巢癌和其他上皮性癌患者血清HE4、CA125水平均高于良性病變患者（P＜0．05），上皮性卵巢癌和其他上皮性癌患者血清 HE4水平比較差異無統計學意義（P＞0．05）。HE4、CA125單項檢測的診斷靈敏度分彆為46．6％和60．3％，聯閤檢測診斷靈敏度為70．7％，較單項檢測明顯提高（ P＜0．05）。以良性疾病患者為參照人群，H E4、CA125單項檢測及二者聯閤檢測的受試者工作特徵麯線下麵積分彆為0．783、0．679和0．791。血清 HE4臨界值設為107．145 pmol／L時，診斷指數最大，靈敏度和特異度分彆為69．0％和78．1％。結論 HE4是靈敏度較高的上皮性癌血清標誌物，與CA125聯閤檢測有助于提高腫瘤的檢齣率和診斷效能，有良好的應用前景。
목적：탐토인부고단백4（HE4）화당련항원125（CA125）연합검측재녀성상피성암진단화감별진단중적응용개치。방법우2011년3월지2012년4월，대58례상피성암화64례량성병변녀성환자진행혈청CA125화HE4검측，분석CA125화HE4재량、악성병변환자중적표체수평급이자연합검측적진단효능。결과상피성란소암화기타상피성암환자혈청HE4、CA125수평균고우량성병변환자（P＜0．05），상피성란소암화기타상피성암환자혈청 HE4수평비교차이무통계학의의（P＞0．05）。HE4、CA125단항검측적진단령민도분별위46．6％화60．3％，연합검측진단령민도위70．7％，교단항검측명현제고（ P＜0．05）。이량성질병환자위삼조인군，H E4、CA125단항검측급이자연합검측적수시자공작특정곡선하면적분별위0．783、0．679화0．791。혈청 HE4림계치설위107．145 pmol／L시，진단지수최대，령민도화특이도분별위69．0％화78．1％。결론 HE4시령민도교고적상피성암혈청표지물，여CA125연합검측유조우제고종류적검출솔화진단효능，유량호적응용전경。
Objective To study the value of combined detection of carbohydrate antigen 125 (CA125) and hu-man epididymis protein 4 (HE4) in the diagnosis of women epithelial carcinoma .Methods From Mar .2011 to Feb . 2012 ,serum levels of CA125 and HE4 were detected in 58 patients with women epithelial carcinoma and 64 patients with gynecological benign diseases .All results were statistically analyzed .Results Serum levels of CA125 and HE4 were significantly higher in patients with ovarian cancer or women epithelial carcinoma than patients with gynecologi-cal benign diseases (P<0 .05) .There was no significant difference between patients with ovarian cancer and patients with women epithelial carcinoma (P>0 .05) .The sensitivity of HE4 and CA125 were 46 .6% and 60 .3% ,respective-ly ,and that of combined detection was 70 .7% ,which was higher than single test (P<0 .05) .Taking patients with gynecological benign diseases as reference group ,the area under receiver operating characteristic curve of single detec-tion of HE4 ,CA125 and combined detected were 0 .783 ,0 .679 and 0 .791 .When the cutoff value of serum HE4 was set at 107 .145 pmol/L ,the Youden index was the biggest ,and the sensitivity and specificity was 69 .0% and 78 .1%respectively .Conclusion Combined detection of CA125 and HE4 could increase the detection rate and improve the diagnostic performance .
