CAJ | 학술논문

目的：探讨原发性肝癌自发性破裂出血的相关危险因素。方法将2006年1月至2012年12月重庆医科大学附属第一医院收治的原发性肝癌自发性破裂出血的56例患者纳入研究组，另选择同期住院肝癌未发生破裂的56例患者纳入对照组。比较两组患者一般情况、实验室检查结果、影像学检查结果等资料。结果对照组与研究组在有无门静脉癌栓、肿瘤突出肝脏表面是否大于1 cm ，以及甲胎蛋白、凝血酶原时间、纤维蛋白原（FIB ）、乙肝病毒e抗原（HBeAg）水平等方面比较差异有统计学意义（P＜0．05）。Logistic回归分析显示肿瘤突出肝脏表面大于1 cm ，以及FIB、HBeAg水平为原发性肝癌自发性破裂出血的独立危险因素。结论肿瘤突出肝脏表面大于1 cm ，以及FIB、HBeAg水平是原发性肝癌自发性破裂出血的独立危险因素。
목적：탐토원발성간암자발성파렬출혈적상관위험인소。방법장2006년1월지2012년12월중경의과대학부속제일의원수치적원발성간암자발성파렬출혈적56례환자납입연구조，령선택동기주원간암미발생파렬적56례환자납입대조조。비교량조환자일반정황、실험실검사결과、영상학검사결과등자료。결과대조조여연구조재유무문정맥암전、종류돌출간장표면시부대우1 cm ，이급갑태단백、응혈매원시간、섬유단백원（FIB ）、을간병독e항원（HBeAg）수평등방면비교차이유통계학의의（P＜0．05）。Logistic회귀분석현시종류돌출간장표면대우1 cm ，이급FIB、HBeAg수평위원발성간암자발성파렬출혈적독립위험인소。결론종류돌출간장표면대우1 cm ，이급FIB、HBeAg수평시원발성간암자발성파렬출혈적독립위험인소。
Objective To study the risk factors relating to spontaneous rupture of hepatocellular carcinoma . Methods A total of 56 patients with spontaneous rupture of hepatocellular carcinoma were selected into study group ,and 56 patients without rupture of hepatocellular carcinoma were selected into control group .The general status ,the results of laboratory examination and imageological diagnosis were compared between the two groups from 2006 to 2012 .Results There were significant differences on the portal tumor thrombus ,alpha fetoprotein (AFP) ,tumor protuberated more than 1 cm above the liver surface ,prothrombin time (PT) ,fibrinogen (FIB) , HBeAg between the two groups (P<0 .05) .Multivariate analysis identified that tumor protuberated more than 1 cm above the liver surface ,FIB ,HBeAg were significant independent risk factors for spontaneous rupture of hepatocel-lular carcinoma .Conclusion Tumor protuberated more than 1 cm above the liver surface ,FIB ,HBeAg are signifi-cant independent risk factors for spontaneous rupture of hepatocellular carcinoma .