CAJ | 학술논문

目的：了解铜绿假单胞菌（PAE）感染的临床分布及耐药情况。方法采用VITEK2-compact检测系统对分离菌株进行鉴定和药敏试验检测，回顾性分析 PAE菌株临床分布特点及耐药性。结果共检出1414株PA E ，以痰液检出最多[1126株（79．63％）]，其次为伤口分泌物[88株（6．22％）]。PA E对头孢他啶、头孢吡肟、庆大霉素、阿米卡星、妥布霉素、哌拉西林／他唑巴坦、亚胺培南的耐药率分别为31．61％、22．98％、33．73％、14．07％、31．40％、31．61％、34．23％，对氨苄西林、呋喃妥因、头孢替坦、头孢唑啉、氨苄西林／舒巴坦、复方磺胺甲噁唑均高度耐药，耐药率大于95．00％。2012年妥布霉素、哌拉西林／他唑巴坦耐药率较2011年明显下降（ P＜0．05）。结论氨基糖苷类、头孢他啶、头孢吡肟、哌拉西林／他唑巴坦、亚胺培南可作为治疗PA E感染的经验用药。
목적：료해동록가단포균（PAE）감염적림상분포급내약정황。방법채용VITEK2-compact검측계통대분리균주진행감정화약민시험검측，회고성분석 PAE균주림상분포특점급내약성。결과공검출1414주PA E ，이담액검출최다[1126주（79．63％）]，기차위상구분비물[88주（6．22％）]。PA E대두포타정、두포필우、경대매소、아미잡성、타포매소、고랍서림／타서파탄、아알배남적내약솔분별위31．61％、22．98％、33．73％、14．07％、31．40％、31．61％、34．23％，대안변서림、부남타인、두포체탄、두포서람、안변서림／서파탄、복방광알갑오서균고도내약，내약솔대우95．00％。2012년타포매소、고랍서림／타서파탄내약솔교2011년명현하강（ P＜0．05）。결론안기당감류、두포타정、두포필우、고랍서림／타서파탄、아알배남가작위치료PA E감염적경험용약。
Objective To study the prevalence and drug resistance of Pseudomonas aeruginosa (PAE) strains . Methods Identification and drug sensitivity of PAE strains were detected by using VITEK 2-compact system .Clini-cal distribution and drug resistance were retrospectively analyzed .Results A total of 1 414 PAE strains were isola-ted ,1 126(79 .63% ) of which were isolated from sputum ,and 88(6 .22% ) strains were isolated from wound speci-mens .Resistant rates of PAE strains to ceftazidime ,cefepime ,gentamicin ,amikacin ,tobramycin ,piperacillin-tazobac-tam and imipenem were 31 .61% ,22 .98% ,33 .73% ,14 .07% ,31 .40% ,31 .61% and 34 .23% .Resistant rates of PAE strains to ampicillin ,nitrofurantoin ,cefotetan ,cefazolin ,ampicillin-sulbactam and trimethoprim-sulfamethoxozole were over 95% .Resistant rates of PAE strains to tobramycin and piperacillin-tazobactam in 2012 were lower than those in 2011 .Conclusion Aminoglycosides ,ceftazidime ,cefepime ,piperacillin-tazobactam and imipenem could be the most sensitive antibiotics to treat PAE infection .