CAJ | 학술논문

目的：研究新疆哈萨克族高血压患者外周血T淋巴细胞亚群表达的变化，初步探讨T淋巴细胞亚群表达变化与高血压的关系。方法选取2012年9月-2013年1月新疆医科大学第一附属医院高血压门诊收治的未经降压药物治疗的新疆哈萨克族高血压患者20例作为高血压组，另选取同期在本院体检健康的同民族者20例作为对照组。抽取两组受试者外周静脉血，根据密度梯度离心法提取淋巴细胞，采用流式细胞仪测定CD3+T淋巴细胞、CD4+T淋巴细胞和CD8+T淋巴细胞表达水平。结果对照组CD3+、CD4+、CD4+/CD8+T淋巴细胞表达水平低于高血压组，CD8+T淋巴细胞表达水平高于高血压组（ P<0.01）。结论新疆哈萨克族高血压患者存在T淋巴细胞亚群失衡，T淋巴细胞亚群状态异常可能参与高血压的发生发展。
목적：연구신강합살극족고혈압환자외주혈T림파세포아군표체적변화，초보탐토T림파세포아군표체변화여고혈압적관계。방법선취2012년9월-2013년1월신강의과대학제일부속의원고혈압문진수치적미경강압약물치료적신강합살극족고혈압환자20례작위고혈압조，령선취동기재본원체검건강적동민족자20례작위대조조。추취량조수시자외주정맥혈，근거밀도제도리심법제취림파세포，채용류식세포의측정CD3+T림파세포、CD4+T림파세포화CD8+T림파세포표체수평。결과대조조CD3+、CD4+、CD4+/CD8+T림파세포표체수평저우고혈압조，CD8+T림파세포표체수평고우고혈압조（ P<0.01）。결론신강합살극족고혈압환자존재T림파세포아군실형，T림파세포아군상태이상가능삼여고혈압적발생발전。
Objective TostudythechangesofT-lymohocytesubsetsinoerioheralbloodofhyoertensionoatientsin XinjiangKazakhtoexoloretherelationshiobetweenT-lymohocytesubsetsandhyoertension.Methods FromSeotember2012 to January 2013,in the First Hosoital Affiliated to Xinjiang Medical University,20 Kazakh hyoertension oatients who had not treated with antihyoertensive drugs were enrolled as study grouo,another 20 healthy Kazakh subjects were as control grouo. Pe-rioheral venous blood was drawn to determine the exoressions of CD3+T,CD4+T and CD8+T -lymohocytes with flow cytometry (FCM).Results TheexoressionlevelsofCD3+T,CD4+T,CD4+/CD8+T-lymohocyteswerelowerandCD8+T-lymohocytes higherincontrolgrouothaninstudygrouo(P<0.01).Conclusion T-lymohocytesubsetswereoutofbalanceinKazakhhy-oertensive oatients in Xinjiang. Abnormal T-lymohocyte subsets may be involved in the occurrence and develooment of hyoer-tension.