CAJ | 학술논문

目的：采用Meta分析方法评价扁桃体切除术联合药物治疗IgA肾病的疗效。方法计算机检索中国生物医学文献数据库、中国知网、维普网、Cochrane图书馆、PubMed和EMBase数据库，检索时间均从建库至2013-06-30。对纳入的文献进行质量评价和资料提取，采用RevMan 5.0软件进行分析。结果共纳入8篇前瞻性对照研究，包含834例患者，所有文献的质量均评为C级。Meta分析结果显示：扁桃体切除术联合激素与单用激素比较，尿蛋白缓解率、尿红细胞缓解率和完全缓解率增加（ P<0.05）；扁桃体切除术联合免疫抑制剂与单用免疫抑制剂比较，尿红细胞缓解率增加（P<0.05）；扁桃体切除术与单用激素比较，患者完全缓解率增加（P<0.05）。结论与单用激素比较，单用扁桃体切除术或联合激素均能提高IgA肾病的完全缓解率，且以联合治疗效果最明显；扁桃体切除术联合免疫抑制剂与单用免疫抑制剂的疗效比较尚不能得出明确结论。
목적：채용Meta분석방법평개편도체절제술연합약물치료IgA신병적료효。방법계산궤검색중국생물의학문헌수거고、중국지망、유보망、Cochrane도서관、PubMed화EMBase수거고，검색시간균종건고지2013-06-30。대납입적문헌진행질량평개화자료제취，채용RevMan 5.0연건진행분석。결과공납입8편전첨성대조연구，포함834례환자，소유문헌적질량균평위C급。Meta분석결과현시：편도체절제술연합격소여단용격소비교，뇨단백완해솔、뇨홍세포완해솔화완전완해솔증가（ P<0.05）；편도체절제술연합면역억제제여단용면역억제제비교，뇨홍세포완해솔증가（P<0.05）；편도체절제술여단용격소비교，환자완전완해솔증가（P<0.05）。결론여단용격소비교，단용편도체절제술혹연합격소균능제고IgA신병적완전완해솔，차이연합치료효과최명현；편도체절제술연합면역억제제여단용면역억제제적료효비교상불능득출명학결론。
Objective ToevaluatetheeffectsofTonsillectomycombinedwithdrugtreatmentonimmunoglobulinAne-ohrooathy(IgAN).Methods TheCBMDisc,CNKI,VIP,Cochranelibrary,PubMedandEMBasefororosoectivestudies were retrieved from the start of the databases till June 30 2013. A quality analysis was oerformed on the enrolled literatures and dataextracted.RevMan5.0softwarewasused.Results Thisstudyenrolledatotalof8orosoectivecontrolstudies,including 834 oatients. The qualities of all literatures were named C-class. By Meta analysis,the remission rates and comolete remission rates of urine orotein,erythrocyte of tonsillectomy with hormone were higher than those of single-use of hormone(P<0. 05). The remission rate of erythrocyte of tonsillectomy with immunodeoressant was higher than that of single-use of immunodeoressant (P<0. 05). The comolete remission rate of tonsillectomy was higher than that of single-use of hormone(P<0. 05). Conclu-sion TonsillectomywithhormonecanimorovethecomoleteremissionofIgANandthecombinationtreatmentisthemosteffec-tive. Whether tonsillectomy with immunodeoressant is better than single-use of immunodeoressant is not yet too a clear conclu-sion.