光明中医
光明中醫
광명중의
GUANG MING JOURNAL TRADITIONAL CHINESE MEDICINE
2014年
9期
1843-1845,1846
,共4页
健脾活血丸%慢性萎缩性胃炎%脾虚络阻证%疗效分析
健脾活血汍%慢性萎縮性胃炎%脾虛絡阻證%療效分析
건비활혈환%만성위축성위염%비허락조증%료효분석
JianPi HuoXue Pill%CAG%Spleen deficiency and Collaterals obstruction Syndrome%curative effect analysis
目的：观察健脾活血丸治疗慢性萎缩性胃炎脾虚络阻证的临床疗效，并探讨其作用机制。方法将符合纳入标准的患者60例随机分成对照组30例和试验组30例。对照组给予胃复春片，每次4片，每日3次，饭前服用。试验组给予健脾活血丸，每次15粒（约7g），每日3次，饭前服用。两组均以12周为一疗程，共治疗1个疗程。比较两组患者临床疗效及治疗前后胃镜象、病理组织学、血流变的改变情况及Hp阴转率。结果试验组总有效率96.67％，对照组76.67％，经比较差异具有统计学意义（ P＜0.05），说明试验组疗效明显优于对照组。试验组胃镜象、病理组织学及血流变改善情况均优于对照组，差异具有统计学意义（P＜0.05）。试验组与对照组对Hp感染均有疗效，但经比较，两组差异无统计学意义（ P＞0.05）。结论健脾活血丸治疗慢性萎缩性胃炎疗效确切，可能与其改善胃黏膜血流、抑制Hp及阻断或逆转胃癌前病变等作用有关。
目的：觀察健脾活血汍治療慢性萎縮性胃炎脾虛絡阻證的臨床療效，併探討其作用機製。方法將符閤納入標準的患者60例隨機分成對照組30例和試驗組30例。對照組給予胃複春片，每次4片，每日3次，飯前服用。試驗組給予健脾活血汍，每次15粒（約7g），每日3次，飯前服用。兩組均以12週為一療程，共治療1箇療程。比較兩組患者臨床療效及治療前後胃鏡象、病理組織學、血流變的改變情況及Hp陰轉率。結果試驗組總有效率96.67％，對照組76.67％，經比較差異具有統計學意義（ P＜0.05），說明試驗組療效明顯優于對照組。試驗組胃鏡象、病理組織學及血流變改善情況均優于對照組，差異具有統計學意義（P＜0.05）。試驗組與對照組對Hp感染均有療效，但經比較，兩組差異無統計學意義（ P＞0.05）。結論健脾活血汍治療慢性萎縮性胃炎療效確切，可能與其改善胃黏膜血流、抑製Hp及阻斷或逆轉胃癌前病變等作用有關。
목적：관찰건비활혈환치료만성위축성위염비허락조증적림상료효，병탐토기작용궤제。방법장부합납입표준적환자60례수궤분성대조조30례화시험조30례。대조조급여위복춘편，매차4편，매일3차，반전복용。시험조급여건비활혈환，매차15립（약7g），매일3차，반전복용。량조균이12주위일료정，공치료1개료정。비교량조환자림상료효급치료전후위경상、병리조직학、혈류변적개변정황급Hp음전솔。결과시험조총유효솔96.67％，대조조76.67％，경비교차이구유통계학의의（ P＜0.05），설명시험조료효명현우우대조조。시험조위경상、병리조직학급혈류변개선정황균우우대조조，차이구유통계학의의（P＜0.05）。시험조여대조조대Hp감염균유료효，단경비교，량조차이무통계학의의（ P＞0.05）。결론건비활혈환치료만성위축성위염료효학절，가능여기개선위점막혈류、억제Hp급조단혹역전위암전병변등작용유관。
Objective To observe the efficacy of JianPi HuoXue Pill in treating Spleen Deficiency and Collaterals Obstruction Syndrome of Chronic Atrophic Gastritis ( CAG ) , and explore the mechanism .Methods Patients in 60 cases of CAG were randomly divided into 2 groups .Test group in 30 cases were treated with “JianPi HuoXue Pill”and control group in 30 cases were treated with “WeiFuChun Tablet”. The treatment course of two groups was 12 weeks.We observed the curative effect of clinical symptoms , gastroscopy signs and pathology , the eradication rate of H.pylori, and the hemorheology after one course of treatment .Then we analyzed them statistically .Results The total effect rate of the test group and the control group was 96.67% and 76.67% respectively .The difference was significant statistically ( P<0.05).The changes of gastroscopy signs and pathology ,the hemorheology between two groups had significant differences (P<0.05),but the negative conversion rate of H .pylori had no obvious statistical significance ( P>0.05 ) .Conclusion The effect of JianPi HuoXue Pill in treating CAG is definite , which can improve the gastric mucosal microcirculation , inhibit the inflammatory response , block and reverse the precancerous lesions .
