CAJ | 학술논문

目的：探讨传统抗癫痫药、抗癫痫新药及中医药或维吾尔医药治疗对癫痫患儿睡眠呼吸的影响。方法将85例患者随机分为传统抗癫痫药物组（A组，30例）、抗癫痫新药组（B组，28例）、中医药或维吾尔医药治疗组（C组，27例），分别在治疗前、治疗1 a后、治疗2 a后及治疗3 a后在非发作期用多导睡眠监测仪（PSG）测定并记录患儿睡眠期图形，判定并分析在长期治疗前后患儿的睡眠呼吸失常的相关指标状况，将3组间睡眠呼吸状况参数进行对比。结果 PSG测定发现治疗前3组患儿总体睡眠呼吸障碍发生百分率为5．50％，呼吸暂停低通气指数（AHI）为（7．23±0．21），均为轻度阻塞性睡眠呼吸暂停低通气综合征；治疗1 a后的发生百分率为6．12％， AHI为（7．56±0．32）；治疗2 a后的发生百分率为6．23％，AHI为（8．65±0．37），其中 A、C组各发现1例轻度中枢性睡眠呼吸暂停低通气综合征；治疗3 a后的发生百分率为6．65％；AHI为（12．56±0．47），其中A、C组各发现1例轻度和中度混合型睡眠呼吸暂停低通气综合征，同时 A组检测出中枢型睡眠呼吸暂停低通气综合征1例。治疗前后睡眠呼吸障碍发生百分率和 AHI差异均有统计学意义（P ＜0．05）；组间比较睡眠呼吸障碍发生百分率和 AHI差异均有统计学意义（P ＜0．05）。结论长期使用抗癫痫药物可加重失眠，有镇静作用的抗痫药物还会加重睡眠期呼吸暂停的危险，但新型抗癫痫药物具有促进睡眠稳定性和正常化的作用，要根据睡眠结构和对睡眠呼吸障碍的影响选择抗癫痫药物。
목적：탐토전통항전간약、항전간신약급중의약혹유오이의약치료대전간환인수면호흡적영향。방법장85례환자수궤분위전통항전간약물조（A조，30례）、항전간신약조（B조，28례）、중의약혹유오이의약치료조（C조，27례），분별재치료전、치료1 a후、치료2 a후급치료3 a후재비발작기용다도수면감측의（PSG）측정병기록환인수면기도형，판정병분석재장기치료전후환인적수면호흡실상적상관지표상황，장3조간수면호흡상황삼수진행대비。결과 PSG측정발현치료전3조환인총체수면호흡장애발생백분솔위5．50％，호흡잠정저통기지수（AHI）위（7．23±0．21），균위경도조새성수면호흡잠정저통기종합정；치료1 a후적발생백분솔위6．12％， AHI위（7．56±0．32）；치료2 a후적발생백분솔위6．23％，AHI위（8．65±0．37），기중 A、C조각발현1례경도중추성수면호흡잠정저통기종합정；치료3 a후적발생백분솔위6．65％；AHI위（12．56±0．47），기중A、C조각발현1례경도화중도혼합형수면호흡잠정저통기종합정，동시 A조검측출중추형수면호흡잠정저통기종합정1례。치료전후수면호흡장애발생백분솔화 AHI차이균유통계학의의（P ＜0．05）；조간비교수면호흡장애발생백분솔화 AHI차이균유통계학의의（P ＜0．05）。결론장기사용항전간약물가가중실면，유진정작용적항간약물환회가중수면기호흡잠정적위험，단신형항전간약물구유촉진수면은정성화정상화적작용，요근거수면결구화대수면호흡장애적영향선택항전간약물。
Objective To investigate the influence of antiepileptic drugs on sleep apnea in children by using polysomnography (PSG).Methods Clinical randomized controlled method was used from February 2010 to February,2013,85 cases were diagnosed clinically as idiopathic epilepsy,using the traditional AEDs with 30 cases in Group A,using new AEDs with 28 cases in Group B,using Chinese medicine or Uyghur medicine with non-AEDs 27 cases in Group C.Sleep apnea condition parameters of three groups were com-pared by using polysomnography (PSG)monitoring.Results The incidence of sleep apnea in three groups before using drugs with mild obstructive sleep apnea hypopnea syndrome was 5.50%,AHI was (7.23 ± 0.21);one year later,the incidence was 6.12%,AHI was (7.56±0.32);two years later,the incidence be-came 6.23%,AHI was (8.65±0.37),including two cases with mild obstructive sleep apnea hypopnea syn-drome;the incidence of the third year was 6.65%,AHI was (12.56±0.47),with one mild obstructive sleep apnea hypopnea syndrom case and one central sleep apnea syndrome case in Group A,one Moderate obstructive sleep apnea hypopnea syndrom case in Group C ,the difference was statistically significant (P<0.05);the difference among the three groups was statistically significant (P <0.05).Conclusion The interaction between epilepsy and sleep disorders,long-term use of antiepileptic drugs can cause insomnia, sedative anti-epileptic drugs also increase the apnea,but the new antiepileptic drugs can promote sleep stabil-ity and normalization to antiepileptic drugs selected according to the structure of sleep and sleep disorders.