新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2014年
10期
1276-1278
,共3页
沈谷群%周萍%程静新%张国庆%姚立丽
瀋穀群%週萍%程靜新%張國慶%姚立麗
침곡군%주평%정정신%장국경%요립려
宫颈鳞癌%鳞状上皮内病变%人乳头瘤病毒负荷量
宮頸鱗癌%鱗狀上皮內病變%人乳頭瘤病毒負荷量
궁경린암%린상상피내병변%인유두류병독부하량
squamous cervical cancer%squamous intraepithelial lesion%Human papillomavirus load
目的:探讨高危型 HPV负荷量与新疆维吾尔族宫颈鳞状细胞癌及癌前病变的相关性。方法采用HC-2的方法,对2011年1月-2013年12月在新疆医科大学附属肿瘤医院就诊的759例维吾尔族患者进行高危型 HPV负荷量的测定,其中宫颈鳞癌组283例,高级别鳞状上皮内病变(HSIL)组266例,低级别鳞状上皮内病变(LSIL)组210例。对高危型 HPV的负荷量与宫颈病变程度进行相关分析,并以同期在我院体检中心体检的维吾尔族女性549例作为对照组。结果对照组、LSIL组、HSIL组及宫颈鳞癌组维吾尔族女性人群间高危型 HPV阳性率比较差异有统计学意义(P =0.000),高危型 HPV-DNA负荷量随疾病程度的加重而增加,呈正相关(P =0.000,r=0.436)。结论在新疆维吾尔族宫颈鳞癌患者及其癌前病变患者中,高危型 HPV负荷量与宫颈病变的程度呈正相关。
目的:探討高危型 HPV負荷量與新疆維吾爾族宮頸鱗狀細胞癌及癌前病變的相關性。方法採用HC-2的方法,對2011年1月-2013年12月在新疆醫科大學附屬腫瘤醫院就診的759例維吾爾族患者進行高危型 HPV負荷量的測定,其中宮頸鱗癌組283例,高級彆鱗狀上皮內病變(HSIL)組266例,低級彆鱗狀上皮內病變(LSIL)組210例。對高危型 HPV的負荷量與宮頸病變程度進行相關分析,併以同期在我院體檢中心體檢的維吾爾族女性549例作為對照組。結果對照組、LSIL組、HSIL組及宮頸鱗癌組維吾爾族女性人群間高危型 HPV暘性率比較差異有統計學意義(P =0.000),高危型 HPV-DNA負荷量隨疾病程度的加重而增加,呈正相關(P =0.000,r=0.436)。結論在新疆維吾爾族宮頸鱗癌患者及其癌前病變患者中,高危型 HPV負荷量與宮頸病變的程度呈正相關。
목적:탐토고위형 HPV부하량여신강유오이족궁경린상세포암급암전병변적상관성。방법채용HC-2적방법,대2011년1월-2013년12월재신강의과대학부속종류의원취진적759례유오이족환자진행고위형 HPV부하량적측정,기중궁경린암조283례,고급별린상상피내병변(HSIL)조266례,저급별린상상피내병변(LSIL)조210례。대고위형 HPV적부하량여궁경병변정도진행상관분석,병이동기재아원체검중심체검적유오이족녀성549례작위대조조。결과대조조、LSIL조、HSIL조급궁경린암조유오이족녀성인군간고위형 HPV양성솔비교차이유통계학의의(P =0.000),고위형 HPV-DNA부하량수질병정도적가중이증가,정정상관(P =0.000,r=0.436)。결론재신강유오이족궁경린암환자급기암전병변환자중,고위형 HPV부하량여궁경병변적정도정정상관。
Objective To investigate the correlation between high-risk human papilloma virus (HR-HPV) load and the grade of cervical lesions of Uyghur Ethnic group.Methods Using HC2 testing determined HR-HPV load for 759 cases of Uyghur patients which covered 210 cases of low-grade squamous intraepi-thelial lesion (LSIL),266 cases of high-grade squamous intraepithelial lesion (HSIL),283 cases of squa-mous cervical cancer in Affiliated Tumor Hospital of Xinjiang Medical University from January 2011 to De-cember 2013,549 cases Uyghur women were recruited as control group from our hospital medical center during the same period.Correlative analysis was made between HR-HPV load and the grade of cervical le-sions.Results HR-HPV load was significantly different (P =0.000)among the patient with squamous cervical cancer,HSIL,LSIL and control group.The result showed positive correlation between HR-HPV load and the grade of cervical lesions (P=0.000,r=0.436).Conclusions The HR-HPV load was positive-ly correlated with the occurrence of squamous cervical cancer and SIL of Uyghur Ethnic group in Xinjing.