环球中医药
環毬中醫藥
배구중의약
GLOBAL TCM
2014年
10期
813-816
,共4页
中药%肿瘤%细胞周期
中藥%腫瘤%細胞週期
중약%종류%세포주기
Traditional Chinese medicine%Tumor%Cell cycle
越来越多的学者已达成共识：肿瘤是一类细胞周期性疾病。细胞周期的调控依赖多种细胞因子的共同参与，其调控机制异常与肿瘤的发生、发展密切相关。随着对中药抗肿瘤研究的深入，发现许多中药复方、单味中药和中药有效成分能够将肿瘤细胞阻滞于不同的细胞周期，从而抑制肿瘤细胞增殖并诱导凋亡。本文将对中药阻滞肿瘤细胞周期的研究做一综述。细胞周期的调控依赖多种细胞因子的共同参与，其调控机制异常与肿瘤的发生、发展密切相关。细胞周期的调控主要由细胞周期蛋白（Cyclins）、细胞周期蛋白依赖性激酶（cyclin-dependent kinases， CDKs）和细胞周期蛋白依赖性激酶抑制物（ cyclin-dependent kinase inhibitors ， CDKIs）进行调控。细胞周期蛋白主要分为Cyclin A、B、C、D、E、F、G、H、I、K十大类。随着对中药抗肿瘤研究的深入，发现许多中药复方、单味中药和中药有效成分能够将肿瘤细胞阻滞于不同的细胞周期，从而抑制肿瘤细胞增殖并诱导凋亡。抗肿瘤中药在细胞周期中主要阻滞细胞于G0/G1期、S期及G2/M期。
越來越多的學者已達成共識：腫瘤是一類細胞週期性疾病。細胞週期的調控依賴多種細胞因子的共同參與，其調控機製異常與腫瘤的髮生、髮展密切相關。隨著對中藥抗腫瘤研究的深入，髮現許多中藥複方、單味中藥和中藥有效成分能夠將腫瘤細胞阻滯于不同的細胞週期，從而抑製腫瘤細胞增殖併誘導凋亡。本文將對中藥阻滯腫瘤細胞週期的研究做一綜述。細胞週期的調控依賴多種細胞因子的共同參與，其調控機製異常與腫瘤的髮生、髮展密切相關。細胞週期的調控主要由細胞週期蛋白（Cyclins）、細胞週期蛋白依賴性激酶（cyclin-dependent kinases， CDKs）和細胞週期蛋白依賴性激酶抑製物（ cyclin-dependent kinase inhibitors ， CDKIs）進行調控。細胞週期蛋白主要分為Cyclin A、B、C、D、E、F、G、H、I、K十大類。隨著對中藥抗腫瘤研究的深入，髮現許多中藥複方、單味中藥和中藥有效成分能夠將腫瘤細胞阻滯于不同的細胞週期，從而抑製腫瘤細胞增殖併誘導凋亡。抗腫瘤中藥在細胞週期中主要阻滯細胞于G0/G1期、S期及G2/M期。
월래월다적학자이체성공식：종류시일류세포주기성질병。세포주기적조공의뢰다충세포인자적공동삼여，기조공궤제이상여종류적발생、발전밀절상관。수착대중약항종류연구적심입，발현허다중약복방、단미중약화중약유효성분능구장종류세포조체우불동적세포주기，종이억제종류세포증식병유도조망。본문장대중약조체종류세포주기적연구주일종술。세포주기적조공의뢰다충세포인자적공동삼여，기조공궤제이상여종류적발생、발전밀절상관。세포주기적조공주요유세포주기단백（Cyclins）、세포주기단백의뢰성격매（cyclin-dependent kinases， CDKs）화세포주기단백의뢰성격매억제물（ cyclin-dependent kinase inhibitors ， CDKIs）진행조공。세포주기단백주요분위Cyclin A、B、C、D、E、F、G、H、I、K십대류。수착대중약항종류연구적심입，발현허다중약복방、단미중약화중약유효성분능구장종류세포조체우불동적세포주기，종이억제종류세포증식병유도조망。항종류중약재세포주기중주요조체세포우G0/G1기、S기급G2/M기。
More and more scholars have reached a consensus: tumor is a kind of cell cycle dis-ease.Participating in the regulation of cell cycle depends on a variety of cytokines .The abnormal regulato-ry mechanism is closely related to the occurrence and development of tumor .With the deepening of antican-cer researches on traditional Chinese medicine it is found that many Chinese herbal compounds , single herb and effective components of traditional Chinese medicine can block tumor cells in different periods of cell cycle, inhibit the proliferation of tumor cells and induce apoptosis .This paper aims to research on tradi-tional Chinese medicine blocking cell cycle of tumor cells .Participating in the regulation of cell cycle de-pends on a variety of cytokines .The abnormal regulatory mechanism is closely related to the occurrence and development of tumor .Cell cycle is regulated by Cyclins , CDKs and CDKIs.Cyclins are divided into Cyc-lin A, B, C, D, E, F, G, H, I and K.With the deepening of anticancer researches on traditional Chi-nese medicine, it is found that many Chinese herbal compounds , single herb and effective components of traditional Chinese medicine can block tumor cells in different periods of cell cycle , inhibit the proliferation of tumor cells and induce apoptosis .Anti-tumor medicines primarily arrest cells in G 0 /G1 period, S peri-od and G2 /M period of cell cycle .
