海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2014年
17期
2525-2527
,共3页
醒脑静%血塞通%脑梗死%效果
醒腦靜%血塞通%腦梗死%效果
성뇌정%혈새통%뇌경사%효과
Xingnaojing%Xuesaitong%Cerebral infarction%Effect
目的：比较醒脑静联合血塞通和依达拉奉联合血塞通治疗脑梗死的临床疗效。方法选取2012年3月至2013年11月海南省农垦那大医院和海南省中医院收治的54例脑梗死患者，按照随机数字表法将其分为试验组和对照组各27例，试验组患者应用醒脑静注射液联合血塞通治疗，对照组患者应用依达拉奉注射液联合血塞通治疗。观察两组患者治疗前、治疗14 d和21 d的血清丙二醛(MDA)、超氧化物歧化酶(SOD)和白三烯的动态改变。以神经功能缺损评分(ESS)和日常生活能力缺陷评分(ADL)以增分率判断两组患者的疗效。结果试验组和对照组的有效率分别为77.78%和37.04%，其差异具有统计学意义(χ2=9.552，P=0.023)；试验组不同时间点MDA、SOD及白三烯的变化差异均有统计学意义(F=18.65，P<0.001；F=11.54，P<0.001；F=13.45，P<0.001)；对照组MDA及SOD不同时间点差异也具有统计学意义(F=6.65，P=0.035；F=5.87，P=0.043)；两组患者MDA、SOD及白三烯比较差异具有统计学意义(F=9.65，P=0.009；F=8.76，P=0.011；F=6.73，P=0.032)；并且两组患者不同时间点MDA、SOD及白三烯差异也均具有统计学意义(F=7.03，P=0.028；F=5.96，P=0.043；F=5.67，P=0.046)。结论醒脑静联合血塞通治疗脑梗死的疗效较好。
目的：比較醒腦靜聯閤血塞通和依達拉奉聯閤血塞通治療腦梗死的臨床療效。方法選取2012年3月至2013年11月海南省農墾那大醫院和海南省中醫院收治的54例腦梗死患者，按照隨機數字錶法將其分為試驗組和對照組各27例，試驗組患者應用醒腦靜註射液聯閤血塞通治療，對照組患者應用依達拉奉註射液聯閤血塞通治療。觀察兩組患者治療前、治療14 d和21 d的血清丙二醛(MDA)、超氧化物歧化酶(SOD)和白三烯的動態改變。以神經功能缺損評分(ESS)和日常生活能力缺陷評分(ADL)以增分率判斷兩組患者的療效。結果試驗組和對照組的有效率分彆為77.78%和37.04%，其差異具有統計學意義(χ2=9.552，P=0.023)；試驗組不同時間點MDA、SOD及白三烯的變化差異均有統計學意義(F=18.65，P<0.001；F=11.54，P<0.001；F=13.45，P<0.001)；對照組MDA及SOD不同時間點差異也具有統計學意義(F=6.65，P=0.035；F=5.87，P=0.043)；兩組患者MDA、SOD及白三烯比較差異具有統計學意義(F=9.65，P=0.009；F=8.76，P=0.011；F=6.73，P=0.032)；併且兩組患者不同時間點MDA、SOD及白三烯差異也均具有統計學意義(F=7.03，P=0.028；F=5.96，P=0.043；F=5.67，P=0.046)。結論醒腦靜聯閤血塞通治療腦梗死的療效較好。
목적：비교성뇌정연합혈새통화의체랍봉연합혈새통치료뇌경사적림상료효。방법선취2012년3월지2013년11월해남성농은나대의원화해남성중의원수치적54례뇌경사환자，안조수궤수자표법장기분위시험조화대조조각27례，시험조환자응용성뇌정주사액연합혈새통치료，대조조환자응용의체랍봉주사액연합혈새통치료。관찰량조환자치료전、치료14 d화21 d적혈청병이철(MDA)、초양화물기화매(SOD)화백삼희적동태개변。이신경공능결손평분(ESS)화일상생활능력결함평분(ADL)이증분솔판단량조환자적료효。결과시험조화대조조적유효솔분별위77.78%화37.04%，기차이구유통계학의의(χ2=9.552，P=0.023)；시험조불동시간점MDA、SOD급백삼희적변화차이균유통계학의의(F=18.65，P<0.001；F=11.54，P<0.001；F=13.45，P<0.001)；대조조MDA급SOD불동시간점차이야구유통계학의의(F=6.65，P=0.035；F=5.87，P=0.043)；량조환자MDA、SOD급백삼희비교차이구유통계학의의(F=9.65，P=0.009；F=8.76，P=0.011；F=6.73，P=0.032)；병차량조환자불동시간점MDA、SOD급백삼희차이야균구유통계학의의(F=7.03，P=0.028；F=5.96，P=0.043；F=5.67，P=0.046)。결론성뇌정연합혈새통치료뇌경사적료효교호。
Objective To discuss the therapeutic effect of Xingnaojing combined with Xuesaitong in the treat-ment of patients of cerebral infarction. Methods All 54 patients were collected from March 2012 to November 2013 in Hainan Nongken Nada Hospital and Hainan Provincial Hospital of Traditional Chinese Medicine. According to random number table, the patients were divided into two groups. The study group applied Xingnaojing injection combined with Xuesaitong, and the control group used edaravone injection combined with Xuesaitong. Dynamic changes were ob-served with malonyldialdehyde (MDA), superoxide dismutase (SOD) and leukotrienes in two groups before treatment,14 d and 21 d after treatment. ESS and ADL was applied to assess the clinical efficacy. Results The effective rate of was 77.78%in the study group and 37.04%in the control group, with statistically significant difference (χ2=9.552, P=0.023). The difference was statistically significant in MDA, SOD, and leukotrienes at different time points in the study group (F=18.65, P<0.001;F=11.54, P<0.001;F=13.45, P<0.001). The difference was statistically significant in MDA, SOD at different time points in the control group (F=6.65, P=0.035;F=5.87, P=0.043). Statistically significant differ-ence was found in MDA, SOD, and leukotrienes between the two groups (F=9.65, P=0.009; F=8.76, P=0.011; F=6.73, P=0.032). The difference was also statistically significant in MDA, SOD, and leukotrienes at different time points between the two groups (F=7.03, P=0.028;F=5.96, P=0.043;F=5.67, P=0.046). Conclusion The therapeutic effect of Xingnaojing combined with Xuesaitong is better for patients of cerebral infarction.
