海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2014年
17期
2514-2516
,共3页
格林-巴利综合征%酶联免疫吸附法%抗神经节苷脂抗体%MBP
格林-巴利綜閤徵%酶聯免疫吸附法%抗神經節苷脂抗體%MBP
격림-파리종합정%매련면역흡부법%항신경절감지항체%MBP
Guillain-Barre syndrome%Enzyme-linked immunosorbent assay%Anti-ganglioside antibodies%Maltose binding protein (MBP)
目的:通过检测格林-巴利综合征(GBS)患者血清麦芽糖结合蛋白(MBP)和抗神经节苷脂抗体水平,探讨其与格林-巴利综合征亚型及严重度的相关性。方法选用2009年3月至2012年3月在我院治疗的格林-巴利综合征患者90例作为观察组,选取同期其他神经系统疾病患者90例作为对照1组和健康体检者100例作为对照2组。采用酶联免疫吸附法(ELISA)检测三组受试者的血清MBP和抗神经节苷脂抗体水平,并进行对比分析。结果(1)观察组血清MBP水平、抗神经节苷脂抗体阳性率均显著高于对照1组和对照2组,其差异均有统计学意义(P<0.05);对照1组血清中MBP水平显著高于对照2组,两组MBP差异具有统计学意义(P<0.05)。(2)急性炎性脱髓鞘性多发性神经根神经病(AIDP)患者血清MBP水平与急性运动轴索型神经病(AMAN)、急性运动感觉轴索型神经病(AMSAN)及米勒费雪症候群(MFS)比较差异均无统计学意义(P>0.05);AIDP患者血清抗神经节苷脂抗体阳性率显著高于AMAN、AMSAN及MFS ,其差异均有统计学意义(P<0.05)。(3)病情等级越高GBS患者血清中MBP水平、抗神经节苷脂抗体阳性率越高,不同等级间的差异均有统计学意义(P<0.05)。结论 MBP、抗神经节苷脂抗体与格林-巴利综合征严重度呈正相关,抗神经节苷脂抗体可能与格林-巴利综合征亚型AIDP相关。
目的:通過檢測格林-巴利綜閤徵(GBS)患者血清麥芽糖結閤蛋白(MBP)和抗神經節苷脂抗體水平,探討其與格林-巴利綜閤徵亞型及嚴重度的相關性。方法選用2009年3月至2012年3月在我院治療的格林-巴利綜閤徵患者90例作為觀察組,選取同期其他神經繫統疾病患者90例作為對照1組和健康體檢者100例作為對照2組。採用酶聯免疫吸附法(ELISA)檢測三組受試者的血清MBP和抗神經節苷脂抗體水平,併進行對比分析。結果(1)觀察組血清MBP水平、抗神經節苷脂抗體暘性率均顯著高于對照1組和對照2組,其差異均有統計學意義(P<0.05);對照1組血清中MBP水平顯著高于對照2組,兩組MBP差異具有統計學意義(P<0.05)。(2)急性炎性脫髓鞘性多髮性神經根神經病(AIDP)患者血清MBP水平與急性運動軸索型神經病(AMAN)、急性運動感覺軸索型神經病(AMSAN)及米勒費雪癥候群(MFS)比較差異均無統計學意義(P>0.05);AIDP患者血清抗神經節苷脂抗體暘性率顯著高于AMAN、AMSAN及MFS ,其差異均有統計學意義(P<0.05)。(3)病情等級越高GBS患者血清中MBP水平、抗神經節苷脂抗體暘性率越高,不同等級間的差異均有統計學意義(P<0.05)。結論 MBP、抗神經節苷脂抗體與格林-巴利綜閤徵嚴重度呈正相關,抗神經節苷脂抗體可能與格林-巴利綜閤徵亞型AIDP相關。
목적:통과검측격림-파리종합정(GBS)환자혈청맥아당결합단백(MBP)화항신경절감지항체수평,탐토기여격림-파리종합정아형급엄중도적상관성。방법선용2009년3월지2012년3월재아원치료적격림-파리종합정환자90례작위관찰조,선취동기기타신경계통질병환자90례작위대조1조화건강체검자100례작위대조2조。채용매련면역흡부법(ELISA)검측삼조수시자적혈청MBP화항신경절감지항체수평,병진행대비분석。결과(1)관찰조혈청MBP수평、항신경절감지항체양성솔균현저고우대조1조화대조2조,기차이균유통계학의의(P<0.05);대조1조혈청중MBP수평현저고우대조2조,량조MBP차이구유통계학의의(P<0.05)。(2)급성염성탈수초성다발성신경근신경병(AIDP)환자혈청MBP수평여급성운동축색형신경병(AMAN)、급성운동감각축색형신경병(AMSAN)급미륵비설증후군(MFS)비교차이균무통계학의의(P>0.05);AIDP환자혈청항신경절감지항체양성솔현저고우AMAN、AMSAN급MFS ,기차이균유통계학의의(P<0.05)。(3)병정등급월고GBS환자혈청중MBP수평、항신경절감지항체양성솔월고,불동등급간적차이균유통계학의의(P<0.05)。결론 MBP、항신경절감지항체여격림-파리종합정엄중도정정상관,항신경절감지항체가능여격림-파리종합정아형AIDP상관。
Objective To explore the correlation of maltose binding protein (MBP), anti-ganglioside antibod-ies and Guillain-Barre syndrome subtype's severity by detecting serum levels of MBP, anti-ganglioside antibodies in patients with Guillain-Barre syndrome (GBS). Methods Ninety patients with Guillain-Barre syndrome in our hospi-tal from March 2009 to March 2012 were selected as observation group, and 90 patients with neurological diseases were selected as control group 1 and 100 healthy people were chosen as control group 2 at the same time. Then en-zyme-linked immunosorbent assay (ELISA) was used to test the serum levels of MBP and anti-ganglioside antibody in three groups. The results obtained were compared at last. Results (1) The MBP and anti-ganglioside antibodies lev-els in the observation group were significantly higher than those in the control group 1 and control group 2 (P<0.05). The MBP levels in the control group 1 was significantly higher than those in the control group 2 with a statistically sig-nificant difference (P<0.05). (2) There was no difference in the serum MBP level between patients with AIDP and pa-tients with AMAN, AMSAN or MFS (P>0.05). However, the positive rates of serum anti-ganglioside antibodies in pa-tients with AIDP was significantly higher than those in patients with AMAN, AMSAN or MFS with statistically signif-icant differences (P<0.05). (3) The severity of GBS was positive related with the positive rate of MBP and the levels of anti-ganglioside antibodies. Conclusion There is a positive correlation between MBP, anti-ganglioside antibodies and the severity of Guillain-Barre syndrome, and the anti-ganglioside antibodies may be associated with Guil-lain-Barre syndrome subtypes-AIDP.