CAJ | 학술논문

目的：研究磷酸奥司他韦颗粒联合小儿牛黄清心散在治疗小儿季节性流感中的临床效果。方法102例流感患儿随机分为治疗组52例，对照组50例。治疗组在口服磷酸奥司他韦颗粒的基础上加用小儿牛黄清心散治疗，对照组口服磷酸奥司他韦颗粒治疗，两组患者以5d为1个疗程，观测治疗前后平均退热天数、咳嗽/咽痛消失时间、出现高热惊厥例数及进展为肺炎例数。结果治疗组治疗后，在症状消失时间、症状积分降低程度、症状总疗效方面，与对照组相比，差异有统计学意义(P<0.05)。结论磷酸奥司他韦颗粒联合小儿牛黄清心散治疗小儿季节性流感效果显著，联合治疗既能迅速抑制流感病毒，阻断疾病进展，又能有效地控制体温、减轻症状、缩短病程，同时避免了因高热导致的患儿神经系统受累以及不必要的抗生素治疗。可作为小儿流感治疗的首选方法，值得临床推广使用。
목적：연구린산오사타위과립연합소인우황청심산재치료소인계절성류감중적림상효과。방법102례류감환인수궤분위치료조52례，대조조50례。치료조재구복린산오사타위과립적기출상가용소인우황청심산치료，대조조구복린산오사타위과립치료，량조환자이5d위1개료정，관측치료전후평균퇴열천수、해수/인통소실시간、출현고열량궐례수급진전위폐염례수。결과치료조치료후，재증상소실시간、증상적분강저정도、증상총료효방면，여대조조상비，차이유통계학의의(P<0.05)。결론린산오사타위과립연합소인우황청심산치료소인계절성류감효과현저，연합치료기능신속억제류감병독，조단질병진전，우능유효지공제체온、감경증상、축단병정，동시피면료인고열도치적환인신경계통수루이급불필요적항생소치료。가작위소인류감치료적수선방법，치득림상추엄사용。
Objective To research clinical efficacy of oseltamivir phosphate particles combined with pediatric bezoar sedative powder in treating seasonal influenza of children. Methods Divided 102 cases of influenza in children randomly into treatment group (n=52) and control group (n=50). Treatment group took pediatric bezoar sedative powder on the basis of oseltamivir phosphate particles while control group only took oseltamivir phosphate particles, two groups of patients took the medicines 5 d as a course, then researchers recorded the average number of days that each group took on controlling temperature, cough, sore throat and the number of cases of febrile seizures, pneumonia that occurred before and after treatment. Results The outcome of the clinical research showed a significant difference between treatment group and control group in curing seasonal influenza of children (P<0.05). Conclusion Oseltamivir phosphate particles combined with pediatric bezoar sedative powder has a significant effect on curing seasonal influenza of children, which can not only inhibit influenza virus, block disease progression, but also drop temperature, reduce symptoms, shorten duration effectively, protect nervous system of children from fever and avoid unnecessary antibiotic treatment, so it is worth to be widely used in treating seasonal influenza of children as the first choice.