CAJ | 학술논문

目的：研究临床常用治疗心脑血管疾病的三种活血化淤中药注射液（冠心宁、葛根素和灯盏花素）对麻醉大鼠的心脏电活动的影响，进一步确认此类中药注射液在正常剂量和较大剂量时对心电图（CG）的影响。方法采用 BL-420F生物机能实验系统记录大鼠Ⅱ导联 ECG，观察并计算给药前后不同时间点心电图P波、R波、ST段和T波及心率的变化。结果正常剂量的冠心宁等中药注射液的确可引起大鼠的心脏电活动异常改变。3种中药注射液在使用正常剂量和10倍正常剂量时可使心率不同程度减慢、偶发P波倒置（见于葛根素注射液）、R波幅度升高、ST段改变和T波幅度升高的改变及偶发室性早搏等变化，提示冠心宁等中药注射液可致心电异常改变，若长时间使用也有至心肌损伤的潜在可能。引起ECG异常与中药制剂的种类、给药的剂量及给药后不同时相有关。结论3种所研究的活血淤中药注射液导致心电图变化的特点因所用药物的种类、剂量及给药时程而不同。在应用中药制剂治疗过程中，应对心脏损害给予足够关注，及时采取相应措施。
목적：연구림상상용치료심뇌혈관질병적삼충활혈화어중약주사액（관심저、갈근소화등잔화소）대마취대서적심장전활동적영향，진일보학인차류중약주사액재정상제량화교대제량시대심전도（CG）적영향。방법채용 BL-420F생물궤능실험계통기록대서Ⅱ도련 ECG，관찰병계산급약전후불동시간점심전도P파、R파、ST단화T파급심솔적변화。결과정상제량적관심저등중약주사액적학가인기대서적심장전활동이상개변。3충중약주사액재사용정상제량화10배정상제량시가사심솔불동정도감만、우발P파도치（견우갈근소주사액）、R파폭도승고、ST단개변화T파폭도승고적개변급우발실성조박등변화，제시관심저등중약주사액가치심전이상개변，약장시간사용야유지심기손상적잠재가능。인기ECG이상여중약제제적충류、급약적제량급급약후불동시상유관。결론3충소연구적활혈어중약주사액도치심전도변화적특점인소용약물적충류、제량급급약시정이불동。재응용중약제제치료과정중，응대심장손해급여족구관주，급시채취상응조시。
Objective To observe the effects of Chinese traditional herbal injection ( Guan xin ning injection , Ge gen su injection and Deng zhan hua su injection ) for cardiovascular diseases on heart's electrical activity in anesthetized rats and confirm the effect of these Chinese medical injection by intraperitoneal relatively high dose on ECG.Methods Electrocardiogram ( LeadⅡ) was recorded by BL-420 F biofunction laboratory system;the changes of the ECG Wave P , wave R, Segment ST, wave T and the heart rate at different times after the peritoneal injection ( ip) of Chinese traditional herbal injection with or without intraperitoneal were observed and calculated .Results The re-sults showed that these three Chinese traditional herbal injections could induce the alterations of heart 's electrical activity in anesthetized rats.Intraperitoneal after administration of 1 or10 times normal dosage and the heart rate was differentially retarded ( except for saline 10 times nor-mal dosage group),the wave P upside down (Ge gen su injection),the elevation or decrease of ST Segment , the elevation of amplitude of R and T wave in every group , additionally , and premature ventricular accidentally ( Ge gen su injection and Deng zhan hua su injection ).The abnormal waves might appear in the severe cases , indicating Chinese traditional herbal injection could induce abnormal electrical activity in the heart.Long-term administration could causes heart damage.The ECG alterations were related with the type of Chinese traditional herbal injection, the dosage and time-course of administration.Conclusions Three blood-activating and stasis-dissolving injections could cause all kinds of ECG for the type of Chinese herbal medicine dosage and time -course of administration.Much more attention should be paid on the cardiac damages and the aimed measures should be given during Chinese medical injection in action .