CAJ | 학술논문

目的：比较帕利哌酮缓释片与利培酮对男性急性期精神分裂症患者疗效及社会功能的影响。方法83例精神分裂症患者随机分为治疗组42例和对照组41例,进行为期12周的对照研究。治疗组口服推荐剂量帕利哌酮缓释片6 mg/d；对照组口服利培酮片1 mg/d起始,1周内增至4~6 mg/d,两组在治疗前、治疗至4、8、12周末分别采用阳性与阴性症状量表(PANSS)评定疗效,个人和社会功能量表(PSP)评定社会功能,治疗时出现的症状量表(TESS)评定不良反应,同时实验室监测血清催乳素水平。结果研究终点两组有效率差异无统计学意义(χ2=0.001, P>0.05)；两组PANSS评分总分及各因子分均较治疗前下降明显, PSP总分较治疗前显著升高,差异有统计学意义(P<0.05)；治疗至12周末,两组患者血清催乳素均明显升高(P<0.05),对照组尤为显著(P<0.05)。而治疗组催乳素水平在治疗8、12周末较治疗至4周末持续下降,且无相关高崔乳素血症症状。第12周末, TESS评分对照组显著较高(t=-1.67, P<0.05)。两组均无严重不良反应,治疗组更轻微(χ2=3.871, P<0.05)。结论帕利哌酮缓释片治疗急性期男性精神分裂症与利培酮疗效相当,且症状控制快、不良反应小、安全性好,能更好的改善患者社会功能。
목적：비교파리고동완석편여리배동대남성급성기정신분렬증환자료효급사회공능적영향。방법83례정신분렬증환자수궤분위치료조42례화대조조41례,진행위기12주적대조연구。치료조구복추천제량파리고동완석편6 mg/d；대조조구복리배동편1 mg/d기시,1주내증지4~6 mg/d,량조재치료전、치료지4、8、12주말분별채용양성여음성증상량표(PANSS)평정료효,개인화사회공능량표(PSP)평정사회공능,치료시출현적증상량표(TESS)평정불량반응,동시실험실감측혈청최유소수평。결과연구종점량조유효솔차이무통계학의의(χ2=0.001, P>0.05)；량조PANSS평분총분급각인자분균교치료전하강명현, PSP총분교치료전현저승고,차이유통계학의의(P<0.05)；치료지12주말,량조환자혈청최유소균명현승고(P<0.05),대조조우위현저(P<0.05)。이치료조최유소수평재치료8、12주말교치료지4주말지속하강,차무상관고최유소혈증증상。제12주말, TESS평분대조조현저교고(t=-1.67, P<0.05)。량조균무엄중불량반응,치료조경경미(χ2=3.871, P<0.05)。결론파리고동완석편치료급성기남성정신분렬증여리배동료효상당,차증상공제쾌、불량반응소、안전성호,능경호적개선환자사회공능。
Objective To compare the curative effects and influence on social function of paliperidone extended-release tablets and risperidone in the treatment of male patients with acute schizophrenia. Methods A total of 83 cases of schizophrenia were randomly divided into treatment group (n=42) and control group (n=41). The control study lasted for 12 weeks. The treatment group received paliperidone extended-release tablets 6 mg/d by oral administration. The control group recevied risperidone tablets by oral administration, which began with 1 mg/d and increased to 4~6 mg/d after 1 week. Curative effects were evaluated by positive and negative symptoms scale (PANSS) and social function was evaluated by personal and social function of scale (PSP) before the treatment and at the end of the 4th, 8th, 12th week in the treatment. Adverse reactions were evaluated by treatment of symptoms scale (TESS), and serum prolactin levels were monitored. Results The effective rates of the two groups at the end of the research had no significant difference (χ2=0.001, P<0.05). PANSS scores and total scores of the two groups were all significantly lower than before the treatment, and the PSP total scores were remarkably increased. The differences had statistical significance (P<0.05). At the end of the 12th week in treatment, serum prolactin were significantly increased in both groups (P<0.05), and the increase in the control group was much more significant (P<0.05). And serum prolactin level in the treatment at the end of 8th and 12th week continuously declined, compared with the level at the end of the 4th week. There were no related symptoms of hyperprolactinemia. At the end of the 12th week, TESS score was significantly higher in the control group (t=-1.67, P<0.05). There were no serious adverse reactions in both groups, and the reactions in treatment group were more mild (χ2=3.871, P<0.05). Conclusion Paliperidone extended-release tablets and risperidone in the treatment of male patients with acute schizophrenia have similar curative effects, and both treatments have fast symptom control, few adverse reactions and good safety, and can improve the patients' social function.