CAJ | 학술논문

目的：探讨丙种球蛋白与干扰素治疗手足口病并发病毒性脑炎的临床疗效及用药安全性。方法将80例手足口病并发病毒性脑炎患者按照随机数字表法分为三组，其中对照组（综合对症治疗）27例，研究1组（丙种球蛋白）27例和研究2组（干扰素）26例，观察三组临床疗效、病情改善及不良反应发生情况。结果研究1组退热时间、惊厥控制时间、皮疹消退时间、精神症状缓解时间及平均住院时间分别为（3．65±0．28）d、（4．04±0．33）d、（3．86±0．27）d、（5．83±0．36）d和（7．53±0．83）d，均显著少于对照组（t＝8．43、8.58、9．15、9．80、8．96，均P＜0．05）；研究2组退热时间、惊厥控制时间、皮疹消退时间、精神症状缓解时间及平均住院时间分别为（3．92±0．29） d、（4．21±0．32） d、（4．27±0．30） d、（6．32±0．43） d和（8．10±0．72）d，均显著少于对照组（t＝7．99、8．17、8．54、9．18、8．55，均P＜0．05）；但研究1组与研究2组各指标差异均无统计学意义（t＝1．12、2．04、1．67、1．38、2．21，均P＞0．05）；三组不良反应发生率差异无统计学意义（χ2＝2．17，P＞0．05）。结论丙种球蛋白与干扰素治疗手足口病并发病毒性脑炎均具有显著疗效，可迅速改善患者症状，缩短治疗时间，且安全性高，具有较好的临床应用价值。
목적：탐토병충구단백여간우소치료수족구병병발병독성뇌염적림상료효급용약안전성。방법장80례수족구병병발병독성뇌염환자안조수궤수자표법분위삼조，기중대조조（종합대증치료）27례，연구1조（병충구단백）27례화연구2조（간우소）26례，관찰삼조림상료효、병정개선급불량반응발생정황。결과연구1조퇴열시간、량궐공제시간、피진소퇴시간、정신증상완해시간급평균주원시간분별위（3．65±0．28）d、（4．04±0．33）d、（3．86±0．27）d、（5．83±0．36）d화（7．53±0．83）d，균현저소우대조조（t＝8．43、8.58、9．15、9．80、8．96，균P＜0．05）；연구2조퇴열시간、량궐공제시간、피진소퇴시간、정신증상완해시간급평균주원시간분별위（3．92±0．29） d、（4．21±0．32） d、（4．27±0．30） d、（6．32±0．43） d화（8．10±0．72）d，균현저소우대조조（t＝7．99、8．17、8．54、9．18、8．55，균P＜0．05）；단연구1조여연구2조각지표차이균무통계학의의（t＝1．12、2．04、1．67、1．38、2．21，균P＞0．05）；삼조불량반응발생솔차이무통계학의의（χ2＝2．17，P＞0．05）。결론병충구단백여간우소치료수족구병병발병독성뇌염균구유현저료효，가신속개선환자증상，축단치료시간，차안전성고，구유교호적림상응용개치。
Objective To investigate the clinical efficacy and safety of intravenous immunoglobulin and interferon in the treatment of hand foot and mouth disease complicated with viral encephalitis .Methods 80 cases of hand foot and mouth disease complicated with viral encephalitis were randomly divided into the three groups according to the random number table .27 cases in the control group were given comprehensive symptomatic treatment ,27 cases in the study group 1 were given gamma globulin ,and 26 cases in the study group 2 were given interferon .The clinical efficacy,improvement of disease ,incidence of adverse reactions of the three groups were compared .Results Defer-vescence time ,seizure control time ,time of skin rash subsided ,time of psychiatric symptoms relieved and the average hospitalization time in the study 1 group were (3.65 ±0.28)d,(4.04 ±0.33)d,(3.86 ±0.27)d,(5.83 ±0.36)d and (7.53 ±0.83)d,which were significantly less than those in the control group (t=8.43,8.58,9.15,9.80,8.96, all P<0.05).Those in the study 2 group were (3.92 ±0.29)d,(4.21 ±0.32)d,(4.27 ±0.30)d,(6.32 ±0.43)d and (8.10 ±0.72)d,which were significantly less than the control group (t=7.99,8.17,8.54,9.18,8.55,all P<0.05);however,there were no significant differences between the study 1 group and the study 2 group(t=1.12, 2.04,1.67,1.38,2.21,all P>0.05).The incidence rate of adverse reaction among the three groups showed no sta-tistically significant difference (χ2 =2.17,P>0.05).Conclusion Intravenous immunoglobulin and interferon have significant effect in the treatment of hand foot mouth disease complicated with viral encephalitis , which can quickly improve symptoms ,shorten treatment time and have high safety and good clinical application value .