CAJ | 학술논문

目的：检测CD133在脑胶质瘤中的表达，探讨其对脑胶质瘤诊断及预后的作用。方法应用辣根过氧化物酶化学法检测38例脑胶质瘤（脑胶质瘤组）和5例正常脑组织（正常对照组）中CD133的表达。结果 CD133在脑胶质瘤组中的阳性表达率为71.1%（27/38），在正常对照组中的表达为0.0（0/5），二者比较，差异有统计学意义（P<0.05）；CD133阳性细胞例数在不同病理级别的脑胶质瘤组织中的表达存在相关性，即胶质瘤级别越高，CD133阳性细胞例数越多，差异有统计学意义（r=0.012，P<0.01）；不同病理级别的脑胶质瘤中CD133阳性细胞率与患者的复发率存在相关性，即不同病理级别的脑胶质瘤中，CD133阳性细胞率越高，患者复发率越高，差异有统计学意义（r=0.358，P<0.05）。结论在脑胶质瘤中CD133的表达情况可以用于指导肿瘤的临床诊断和预后评估。
목적：검측CD133재뇌효질류중적표체，탐토기대뇌효질류진단급예후적작용。방법응용랄근과양화물매화학법검측38례뇌효질류（뇌효질류조）화5례정상뇌조직（정상대조조）중CD133적표체。결과 CD133재뇌효질류조중적양성표체솔위71.1%（27/38），재정상대조조중적표체위0.0（0/5），이자비교，차이유통계학의의（P<0.05）；CD133양성세포례수재불동병리급별적뇌효질류조직중적표체존재상관성，즉효질류급별월고，CD133양성세포례수월다，차이유통계학의의（r=0.012，P<0.01）；불동병리급별적뇌효질류중CD133양성세포솔여환자적복발솔존재상관성，즉불동병리급별적뇌효질류중，CD133양성세포솔월고，환자복발솔월고，차이유통계학의의（r=0.358，P<0.05）。결론재뇌효질류중CD133적표체정황가이용우지도종류적림상진단화예후평고。
Objective To detect the expression of CD133 in brain gliomas,and explore its effect in diagnosis and prog nosis of gliomas. Methods The expression of CD133 in 38 cases of brain glioma(brain glima group) and 5 cases of normal brain tissue(normal control group) was detected by peroxidase horseradish method. Results The positive rate of CD133 was 71.1%(27/38) in the brain glioma group and 0.0(0/5) in the normal control group,and the difference had statistical significance(P<0.05). There was correlation between positive cells of CD133 and the expression in brain glioma tissues in different pathological levels that was the higher the brain gliomas were,the more of the positive cells of CD133 were,and the difference was statistically signif-icant(r=0.012,P<0.01). The correlation between positive rate of CD133 of brain gliomas in different pathological levels and recur-rence rate was that the higher of the positive rate of CD133 was,the higher of the recurrence rate was,and the difference had sta tistically significance(r=0.358,P<0.05). Conclusion The expression of CD133 in brain gliomas can be used to guide the clinical treatment and prognosis.