中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
20期
3098-3099,3100
,共3页
膀胱肿瘤%癌%bin1蛋白%基因,myc%免疫组织化学
膀胱腫瘤%癌%bin1蛋白%基因,myc%免疫組織化學
방광종류%암%bin1단백%기인,myc%면역조직화학
Bladder neoplasms%Carcinoma%Bridging intergrator protein-1%Genes,myc%Immunohistochemistry
目的：探讨bin1、C-myc在膀胱尿路上皮癌组织中的表达及意义。方法采用SP法检测膀胱尿路上皮癌石蜡标本84例，正常膀胱黏膜组织11例bin1、C-myc的表达，并分析其与临床病理特征的关系。结果 bin1在正常膀胱组织中表达阳性率81．81％，膀胱尿路上皮癌组织中表达阳性率46．43％，差异无统计学意义（χ2＝4．873，P＝0．051）。 C-myc 在正常膀胱组织中无表达，膀胱尿路上皮癌组织中表达阳性率52.38％，差异有统计学意义（χ2＝10．733，P＝0．001）。 bin1在浸润型膀胱尿路上皮癌组织中表达明显低于非浸润型（χ2＝7．685，P＝0．007），随着组织分级及UICC 分期增高bin1阳性表达率降低（χ2＝15．817，P＝0.000；χ2＝11．104，P＝0．010）。 C-myc表达强度与组织学分类、组织分级及UICC分期无关。 bin1表达强度与组织学分类、组织分级及UICC分期呈负相关（r＝-0．302，P＝0．005；r＝-0．411，P＝0．000；r＝-0．302， P＝0.005）；随着bin1表达增高C-myc表达降低，但差异无统计学意义。结论 Bin1低表达或表达缺失与膀胱尿路上皮癌病变进展相关，C-myc表达与膀胱尿路上皮癌病变发生有关。提示bin1可能成为膀胱尿路上皮癌预后的预测因子，bin1、C-myc有可能成为肿瘤化疗的一个分子靶向目标。
目的：探討bin1、C-myc在膀胱尿路上皮癌組織中的錶達及意義。方法採用SP法檢測膀胱尿路上皮癌石蠟標本84例，正常膀胱黏膜組織11例bin1、C-myc的錶達，併分析其與臨床病理特徵的關繫。結果 bin1在正常膀胱組織中錶達暘性率81．81％，膀胱尿路上皮癌組織中錶達暘性率46．43％，差異無統計學意義（χ2＝4．873，P＝0．051）。 C-myc 在正常膀胱組織中無錶達，膀胱尿路上皮癌組織中錶達暘性率52.38％，差異有統計學意義（χ2＝10．733，P＝0．001）。 bin1在浸潤型膀胱尿路上皮癌組織中錶達明顯低于非浸潤型（χ2＝7．685，P＝0．007），隨著組織分級及UICC 分期增高bin1暘性錶達率降低（χ2＝15．817，P＝0.000；χ2＝11．104，P＝0．010）。 C-myc錶達彊度與組織學分類、組織分級及UICC分期無關。 bin1錶達彊度與組織學分類、組織分級及UICC分期呈負相關（r＝-0．302，P＝0．005；r＝-0．411，P＝0．000；r＝-0．302， P＝0.005）；隨著bin1錶達增高C-myc錶達降低，但差異無統計學意義。結論 Bin1低錶達或錶達缺失與膀胱尿路上皮癌病變進展相關，C-myc錶達與膀胱尿路上皮癌病變髮生有關。提示bin1可能成為膀胱尿路上皮癌預後的預測因子，bin1、C-myc有可能成為腫瘤化療的一箇分子靶嚮目標。
목적：탐토bin1、C-myc재방광뇨로상피암조직중적표체급의의。방법채용SP법검측방광뇨로상피암석사표본84례，정상방광점막조직11례bin1、C-myc적표체，병분석기여림상병리특정적관계。결과 bin1재정상방광조직중표체양성솔81．81％，방광뇨로상피암조직중표체양성솔46．43％，차이무통계학의의（χ2＝4．873，P＝0．051）。 C-myc 재정상방광조직중무표체，방광뇨로상피암조직중표체양성솔52.38％，차이유통계학의의（χ2＝10．733，P＝0．001）。 bin1재침윤형방광뇨로상피암조직중표체명현저우비침윤형（χ2＝7．685，P＝0．007），수착조직분급급UICC 분기증고bin1양성표체솔강저（χ2＝15．817，P＝0.000；χ2＝11．104，P＝0．010）。 C-myc표체강도여조직학분류、조직분급급UICC분기무관。 bin1표체강도여조직학분류、조직분급급UICC분기정부상관（r＝-0．302，P＝0．005；r＝-0．411，P＝0．000；r＝-0．302， P＝0.005）；수착bin1표체증고C-myc표체강저，단차이무통계학의의。결론 Bin1저표체혹표체결실여방광뇨로상피암병변진전상관，C-myc표체여방광뇨로상피암병변발생유관。제시bin1가능성위방광뇨로상피암예후적예측인자，bin1、C-myc유가능성위종류화료적일개분자파향목표。
Objective To investigate the expression and significance of bin 1,C-myc in bladder urothelial carcinoma.Methods SP method was used to detect the expression of bin 1,C-myc protein in paraffin specimens from bladder urothelial carcinoma of 84 cases and mucosa of 11 cases,and its relationship with clinical pathological charac-teristics was analyzed.Results The positive expression rate of bin1 in normal bladder tissues was 81.81%,that in bladder urothelial carcinoma was 46.43%,the difference was not significant (χ2 =4.873,P=0.051).No expression of C-myc was observed in normal bladder tissue ,the positive expression rate of C-myc in bladder urothelial carcinoma was 52.38%,the difference was statistically significant (χ2 =10.733,P=0.001).The expression of bin1 in invasive bladder urothelial carcinoma was significantly lower than the non-infiltrating type(χ2 =7.685,P =0.007),with increased histological grade and UICC stage ,the positive rate of bin1 expression decreased (χ2 =15.817,P=0.000;χ2 =11.104,P=0.010).The expression of C-myc had no relationship with the histological classification ,histological grade and UICC stage .Correlation analysis showed that the expression of bin 1 was negatively correlated with histologi-cal classification,histological grade and UICC stage (r=-0.302,P=0.005;r=-0.411,P=0.000;r=-0.302, P=0.005).With the increased expression of bin1,C-myc expression decreased,but the difference was not statistical-ly significant.Conclusion Low expression of bin1 or loss of bin1expression were associated with the progression of bladder urothelial carcinoma , the expression of C-myc was related with bladder urothelial carcinoma lesions .The results suggest that bin1 may be predictive factor for prognosis of urinary bladder urothelial carcinomas ;bin1,C-myc may be viewed as molecular targets for tumor chemotherapy .
