CAJ | 학술논문

目的：测定PRKACB蛋白在非小细胞肺癌中的表达情况，研究其临床病理意义，分析其表达与预后的相关性。方法应用免疫组织化学法测定109例非小细胞肺癌及其中对应的20例癌旁组织内PRKACB蛋白水平，结合临床资料及预后随访情况进行多因素分析。结果与癌旁组织相比， PRKACB在109例非小细胞肺癌组织内蛋白水平下调，低表达率（69．7％）显著高于20例癌旁肺组织（10．0％）（χ2＝25.217，P＜0.05）；PRKACB蛋白在非小细胞肺癌组织中的表达与分化程度（χ2＝9．664，P＜0．05）、淋巴结转移情况（χ2＝4．430，P＜0．05）、肿瘤分期（χ2＝4．430，P＜0．05）相关；PRKACB蛋白的低表达与肿瘤患者预后（总生存期及无瘤生存期）不良相关。结论 PRKACB在非小细胞肺癌内呈现低表达，并与临床相关，可能成为非小细胞肺癌临床诊断的一个重要指标。
목적：측정PRKACB단백재비소세포폐암중적표체정황，연구기림상병리의의，분석기표체여예후적상관성。방법응용면역조직화학법측정109례비소세포폐암급기중대응적20례암방조직내PRKACB단백수평，결합림상자료급예후수방정황진행다인소분석。결과여암방조직상비， PRKACB재109례비소세포폐암조직내단백수평하조，저표체솔（69．7％）현저고우20례암방폐조직（10．0％）（χ2＝25.217，P＜0.05）；PRKACB단백재비소세포폐암조직중적표체여분화정도（χ2＝9．664，P＜0．05）、림파결전이정황（χ2＝4．430，P＜0．05）、종류분기（χ2＝4．430，P＜0．05）상관；PRKACB단백적저표체여종류환자예후（총생존기급무류생존기）불량상관。결론 PRKACB재비소세포폐암내정현저표체，병여림상상관，가능성위비소세포폐암림상진단적일개중요지표。
Objective To detect expression of PRKACB protein in non-small cell lung cancer ,thus to study its clinical significance and to analyze the relationship between PRKACB expression and prognosis .Methods We detected the PRKACB protein using immunohistochemistry in 109 lung cancer tissues and corresponding adjacent 20 normal tissues of non-small cell lung cancer patients .Results Compared with normal tissues , the level of PRKACB significantly decreased in lung cancers (χ2 =25.217,P<0.05),and was associated with differentiation (χ2 =9.664,P<0.05),lymph node metastasis(χ2 =4.430,P<0.05),and TNM staging(χ2 =4.430,P<0.05). Furthermore,the low expression of PRKACB protein was correlated with poor prognosis ( overall survival and disease-free survival ) of the patients .Conclusion PRKACB was lowly expressed in non-small cell lung cancer ,and associat-ed with clinical features ,which indicated its important role in clinical diagnosis of non-small cell lung cancer .