CAJ | 학술논문

报道1例原发皮肤结外NK/T细胞淋巴瘤，并复习文献。患者，女，42岁。全身皮肤瘀斑、皮下结节20余天，发热4 d。右股内侧皮损组织病理示：大量淋巴细胞及浆细胞呈弥漫性浸润。免疫组化结果：CD3、CD43、CD56、颗粒酶B(Granzyme B， GгB)、细胞毒性蛋白(TIA)-1均(+)、Ki-67 LI约60%阳性；原位杂交EBER(+)。本病恶性程度高，需尽早进行组织病理检查及免疫组化染色以帮助诊断。
보도1례원발피부결외NK/T세포림파류，병복습문헌。환자，녀，42세。전신피부어반、피하결절20여천，발열4 d。우고내측피손조직병리시：대량림파세포급장세포정미만성침윤。면역조화결과：CD3、CD43、CD56、과립매B(Granzyme B， GгB)、세포독성단백(TIA)-1균(+)、Ki-67 LI약60%양성；원위잡교EBER(+)。본병악성정도고，수진조진행조직병리검사급면역조화염색이방조진단。
To report a case of primary cutaneous extranodal NK/T-cell lymphoma, and the pertinent literature was reviewed. The patient was 42-year-old, female, who suffered from subcutaneous nodules and ecchymosis for 20 days, and recurrent fever for 4 days. Dermatopathology examination showed that there was a widespread infiltration of lymphoid cells; immunohistrochemistry examination results showed that CD3, CD43, CD56, GгB and TIA-1 were positive; Ki-67 LI was about 60% positive; EBER detected by in situ hybridization was positive. The diagnosis was primary cutaneous extranodal NK/T cell lymphoma, which is a high-grade malignancy. The histopathology and immunohistochemistry examination should be carried out as soon as possible so as to get the deifnite diagnosis.