CAJ | 학술논문

目的：分别根据血β2-微球蛋白（β2-MG）、24 h尿蛋白，血浆纤维蛋白原(FG)和D-二聚体(DD)临床检测值，初步评估结节性血管炎患者肾损害和纤溶-凝血系统异常，以及两种异常的相关性，以利于临床上对结节性血管炎患者肾损害和纤溶-凝血系统异常进行早期干预。方法回顾性分析2011年5月-2013年9月34例结节性血管炎患者的血β2-MG、24 h尿蛋白、FG和DD的临床检测值，分别评估结节性血管炎肾损害和纤溶-凝血系异常及其临床意义。结果血β2-MG和24 h尿蛋白同时升高的患者占11.76%，FG和DD同时升高的患者占29.41%，血β2-MG和FG同时升高的患者占11.76%。采用Pearson积矩相关分析显示血β2-MG与FG两变量直线相关系数r=0.7335，P＜0.005，血β2-MG与FG两变量之间存在正相关。结论少部分结节性血管炎患者有肾损害和纤溶-凝血系统异常，且肾损害和纤溶-凝血系统异常具有很高的正相关性，两种异常可能互为危险因素。
목적：분별근거혈β2-미구단백（β2-MG）、24 h뇨단백，혈장섬유단백원(FG)화D-이취체(DD)림상검측치，초보평고결절성혈관염환자신손해화섬용-응혈계통이상，이급량충이상적상관성，이리우림상상대결절성혈관염환자신손해화섬용-응혈계통이상진행조기간예。방법회고성분석2011년5월-2013년9월34례결절성혈관염환자적혈β2-MG、24 h뇨단백、FG화DD적림상검측치，분별평고결절성혈관염신손해화섬용-응혈계이상급기림상의의。결과혈β2-MG화24 h뇨단백동시승고적환자점11.76%，FG화DD동시승고적환자점29.41%，혈β2-MG화FG동시승고적환자점11.76%。채용Pearson적구상관분석현시혈β2-MG여FG량변량직선상관계수r=0.7335，P＜0.005，혈β2-MG여FG량변량지간존재정상관。결론소부분결절성혈관염환자유신손해화섬용-응혈계통이상，차신손해화섬용-응혈계통이상구유흔고적정상관성，량충이상가능호위위험인소。
Objective Through the analysis of the results of the clinical tests including serumβ2-micro-globulin (β2-MG), 24 hour urinary protein, plasma ifbrinogen(FG) and two D-dimer(DD), preliminarily assess the kidney damage and the anomalies of ifbrinolytic and coagulative system and their correlations in the hospitalized patients with vasculitis nodular. The results will provide assistance for the clinician to give an early intervention to the hospitalized patients with erysipelas who suffering from renal damage and the anomalies of ifbrinolytic and coagulative system. Methods Thirty four hospitalized patients with nodular vasculitis from May 2011 to September 2013 were collected and retrospectively analyzed. Laboratory data including serum β2-MG, 24 hour urinary protein, FG and DD of the patients were analyzed, so as to assess the patients’ renal damage and the anomalies of ifbrinolytic and coagulative system. Results Both serum β2-MG and 24 hour urinary protein value were increased in 11.76% of the patients; both FG and DD’ s values were increased in 29.41%of the patients;both Serumβ2-MG and FG were increased in 11.76%of the patients. The result of Pearson product-moment correlation analysis showed that there was a positive correlation between serum β2-MG and FG (variable linear correlation coefifcient r=0.7335, P<0.005). Conclusion A minority of the hospitalized patients with nodular vasculitis were complicated with renal damage and anomalies of ifbrinolytic and coagulative system. Renal damage and the anomalies of ifbrinolytic and coagulative system may affect each other, meanwhile as the risk factors to each other, there is a high positive correlation between the two factors.