CAJ | 학술논문

目的：了解2012-2013年深圳市Beau线/甲脱落的临床特点及其与手足口病（HFMD)的关联情况，并复习相关文献。方法对近2年在本院皮肤科、儿科、传染科门诊诊治的HFMD及Beau线/甲脱落患者临床资料进行分析。结果295例患者中女157例，男138例，平均发病年龄4.25岁，患者均有发热、皮损，皮损消退中位时间为8.7 d（7~14 d）。对其中80例患者行病原学检查，咽拭子聚合酶链反应(PCR)核酸扩增检测，肠病毒71(EV71)28例（35.00%），柯萨奇病毒A16(CA16)7例（8.75%），其他肠病毒5例（6.25%），其余无阳性结果。随访中发现HFMD发病后的4～6周有35例出现了甲损害，这些患者此前均无甲外伤、甲周炎等病史，所有患者甲损害在6周内均恢复。结论与HFMD相关的Beau线/甲脱落机制尚不清楚，且由于其症状较轻，并可自愈，故无需治疗。
목적：료해2012-2013년심수시Beau선/갑탈락적림상특점급기여수족구병（HFMD)적관련정황，병복습상관문헌。방법대근2년재본원피부과、인과、전염과문진진치적HFMD급Beau선/갑탈락환자림상자료진행분석。결과295례환자중녀157례，남138례，평균발병년령4.25세，환자균유발열、피손，피손소퇴중위시간위8.7 d（7~14 d）。대기중80례환자행병원학검사，인식자취합매련반응(PCR)핵산확증검측，장병독71(EV71)28례（35.00%），가살기병독A16(CA16)7례（8.75%），기타장병독5례（6.25%），기여무양성결과。수방중발현HFMD발병후적4～6주유35례출현료갑손해，저사환자차전균무갑외상、갑주염등병사，소유환자갑손해재6주내균회복。결론여HFMD상관적Beau선/갑탈락궤제상불청초，차유우기증상교경，병가자유，고무수치료。
Objective To ifnd out the clinical features of nail dystrophy (e.g., Beau's lines and onychomadesis) and the correlations between onychomadesis/Beau’s lines and hand-foot-mouth disease (HFMD). Methods The data of HFMD patients and onychomadesis/Beau’s lines patients who had had HFMD before in our dermatology, paediatrics and infectious diseases department between March 2012 and March 2013 were analyzed. Results Two hundred and ninty ifve cases of HFMD were detected, female 157 cases, male 138 cases. All the cases resided in Shenzhen metropolitan area, and the mean age was 4.25 years old (range from 3 months to 28 years old). Fever and rash were the most common presenting symptoms. Lesions healed in 8.7 days (range from 7 to 14 days). CA16, EV71 and other enteroviruses (EVs) conifrmed as the viral pathogen. The nail dystrophy (e.g., Beau's lines and onychomadesis) was noted in 35 children within 4 to 6 weeks, and none of these children had a history of nail trauma, periungual dermatitis, periungual vesicular lesions, or a signiifcant medication intake history. For all the patients, the nail changes were temporary with a spontaneous normal regrowth in the subsequent 6 weeks. Conclusion The association of HFMD with Beau's lines and onychomadesis has not been reported previously in China. There was a strong association between HFMD and Beau’s line/onychomadesis. There are many evidences to support a correlation between HFMD and Beau’ s line/onychomadesis, and the mechanism of the nail matrix arrest is unclear. Onychomadesis and/or onycholysis is a newly recognized complication which will occur in the course of viral infections presenting clinically as HFMD, for its mild forms, this complication may be underestimated.