CAJ | 학술논문

目的：探讨瑞格列奈与格列齐特治疗2型糖尿病的临床效果。方法选取2012年5月~2013年6月本院收治的2型糖尿病患者146例，随机分为两组，分别给予瑞格列奈与格列齐特进行治疗，通过测定患者的BMI、FPG、HbA1c、2 h PG等指标，比较两组的疗效。结果两组治疗前的BMI、FPG、HbA1c、2 h PG水平比较，差异无统计学意义(P>0.05)，两组治疗后的BMI、FPG、HbA1c、2 h PG水平较治疗前显著下降，差异有统计学意义(P<0.05)，瑞格列奈组治疗后的BMI、FPG、HbA1c水平显著低于格列齐特组，差异有统计学意义(P<0.05)，两组治疗后的2 h PG水平比较，差异无统计学意义(P>0.05)；瑞格列奈组的总有效率为91.8%，高于格列齐特组的84.9%，差异有统计学意义(P<0.05)。结论瑞格列奈治疗2型糖尿病的效果优于格列齐特。
목적：탐토서격렬내여격렬제특치료2형당뇨병적림상효과。방법선취2012년5월~2013년6월본원수치적2형당뇨병환자146례，수궤분위량조，분별급여서격렬내여격렬제특진행치료，통과측정환자적BMI、FPG、HbA1c、2 h PG등지표，비교량조적료효。결과량조치료전적BMI、FPG、HbA1c、2 h PG수평비교，차이무통계학의의(P>0.05)，량조치료후적BMI、FPG、HbA1c、2 h PG수평교치료전현저하강，차이유통계학의의(P<0.05)，서격렬내조치료후적BMI、FPG、HbA1c수평현저저우격렬제특조，차이유통계학의의(P<0.05)，량조치료후적2 h PG수평비교，차이무통계학의의(P>0.05)；서격렬내조적총유효솔위91.8%，고우격렬제특조적84.9%，차이유통계학의의(P<0.05)。결론서격렬내치료2형당뇨병적효과우우격렬제특。
Objective To explore the clinical effect of repaglinide and gliclazide in the treatment of type 2 diabetes. Methods 146 cases with type 2 diabetes from May 2012 to June 2013 in our hospital were randomly divided into two groups,repaglinide and gliclazide was given to two groups respectively,BMI,FPG,HbA1c,2hPG was detected,the treat-ment effect of two groups was compared respectively. Results Before treatment,there was no statistically significance in the level of BMI,FPG,HbA1c,2 h PG between two groups respectively (P>0.05).After treatment,the level of BMI,FPG, HbA1c,2 h PG in two groups were increased significantly compared with before treatment,with statistical difference (P<0.05),the level of BMI,FPG,HbA1c in repaglinide group after treatment compared with before treatment,the difference was statistically significant(P<0.05),there was no statistically significance in the level of 2 h PG between two groups af-ter treatment (P>0.05).The total effective rate in repaglinide group was 91.8%,higher than that in gliclazide group (84.9%), with statistical difference (P<0.05). Conclusion The clinical effect of type 2 diabetes treated by repaglinide is better than that by gliclazide.