中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
26期
74-76
,共3页
肾病综合征%泼尼松%环磷酰胺
腎病綜閤徵%潑尼鬆%環燐酰胺
신병종합정%발니송%배린선알
Nephrotic syndrome%Prednisone%Cyclophosphamide
目的：观察泼尼松联合环磷酰胺治疗肾病综合征的效果。方法选取本院肾内科收治的50例肾病综合征患者，将其随机均分为对照组与实验组各25例，两组均给予常规治疗，对照组在常规治疗的基础上服用泼尼松，实验组在常规治疗的基础上行泼尼松与环磷酰胺联合治疗，比较两组的治疗效果。结果治疗后两组24 h尿蛋白量、血白蛋白以及血肌酐均有显著改善，与治疗前比较，差异有统计学意义(P<0.05)；且实验组改善效果更优，与对照组比较，差异有统计学意义(P<0.05)。实验组治疗总有效率为96.0%，高于对照组治疗总有效率的68.0%，差异有统计学意义(P<0.05)。实验组不良反应发生率为4.0%，低于对照组的28.0%，差异有统计学意义(P<0.05)。结论泼尼松与环磷酰胺联合治疗肾病综合征，可收到满意效果，且安全性较高，值得临床推广应用。
目的：觀察潑尼鬆聯閤環燐酰胺治療腎病綜閤徵的效果。方法選取本院腎內科收治的50例腎病綜閤徵患者，將其隨機均分為對照組與實驗組各25例，兩組均給予常規治療，對照組在常規治療的基礎上服用潑尼鬆，實驗組在常規治療的基礎上行潑尼鬆與環燐酰胺聯閤治療，比較兩組的治療效果。結果治療後兩組24 h尿蛋白量、血白蛋白以及血肌酐均有顯著改善，與治療前比較，差異有統計學意義(P<0.05)；且實驗組改善效果更優，與對照組比較，差異有統計學意義(P<0.05)。實驗組治療總有效率為96.0%，高于對照組治療總有效率的68.0%，差異有統計學意義(P<0.05)。實驗組不良反應髮生率為4.0%，低于對照組的28.0%，差異有統計學意義(P<0.05)。結論潑尼鬆與環燐酰胺聯閤治療腎病綜閤徵，可收到滿意效果，且安全性較高，值得臨床推廣應用。
목적：관찰발니송연합배린선알치료신병종합정적효과。방법선취본원신내과수치적50례신병종합정환자，장기수궤균분위대조조여실험조각25례，량조균급여상규치료，대조조재상규치료적기출상복용발니송，실험조재상규치료적기출상행발니송여배린선알연합치료，비교량조적치료효과。결과치료후량조24 h뇨단백량、혈백단백이급혈기항균유현저개선，여치료전비교，차이유통계학의의(P<0.05)；차실험조개선효과경우，여대조조비교，차이유통계학의의(P<0.05)。실험조치료총유효솔위96.0%，고우대조조치료총유효솔적68.0%，차이유통계학의의(P<0.05)。실험조불량반응발생솔위4.0%，저우대조조적28.0%，차이유통계학의의(P<0.05)。결론발니송여배린선알연합치료신병종합정，가수도만의효과，차안전성교고，치득림상추엄응용。
Objective To observe the effect of prednisone combined with cyclophosphamide in the treatment of nephrotic syndrome. Methods 50 patients with nephrotic syndrome were admitted in our hospital,and were randomly di-vided into control group and experimental group,25 cases in each group,routine treatment was given to the two groups, prednisone was given to the control group on the basis of conventional treatment,prednisone combined with cyclophos-phamide was added to the experimental group on the basis of conventional treatment.The therapeutic effect of two groups was observed and compared. Results After treatment,the 24 h urinary protein excretion,serum albumin and serum creatinine of two groups improved,compared with before treatment,the difference was significant (P<0.05);and the improvement of experimental group was better than that of the control group,the difference was significant (P<0.05).The total effective rate of experimental group was 96.0%,higher than 68.0% of the control group,the difference was signifi-cant (P<0.05).The incidence of adverse reactions in experimental group was 4.0%,lower than 28.0% of the control group,the difference was significant (P<0.05). Conclusion The efficacy of prednisone combined with cyclophosphamide treating nephrotic syndrome is significant,and has high security,is worth clinical promotion.
