CAJ | 학술논문

目的：探讨芳香化酶抑制剂在妇科内分泌疾病治疗中的应用价值。方法选取2010年8月~2012年8月在本院治疗的妇科内分泌患者90例，分别给予依西美坦(n=36)、阿那曲唑(n=28)和来曲唑(n=26)治疗，观察芳香化酶抑制剂的疗效、3组患者血清雌二醇(E2)抑制情况及不良反应发生情况。结果依西美坦组、阿那曲唑组和来曲唑组的治疗总有效率分别为94.44%、92.86%和92.31%，差异无统计学意义(P>0.05)。治疗后3组患者血清E2水平明显下降，与治疗前比较差异有统计学意义(P<0.05)；依西美坦组患者的血清E2抑制率及有效抑制率优于其他两组(P<0.05)。3组均未出现严重不良反应；在体重增加上来曲唑组尤为显著(P<0.05)。结论芳香化酶抑制剂可有效治疗妇科内分泌疾病，且药物耐受性好。
목적：탐토방향화매억제제재부과내분비질병치료중적응용개치。방법선취2010년8월~2012년8월재본원치료적부과내분비환자90례，분별급여의서미탄(n=36)、아나곡서(n=28)화래곡서(n=26)치료，관찰방향화매억제제적료효、3조환자혈청자이순(E2)억제정황급불량반응발생정황。결과의서미탄조、아나곡서조화래곡서조적치료총유효솔분별위94.44%、92.86%화92.31%，차이무통계학의의(P>0.05)。치료후3조환자혈청E2수평명현하강，여치료전비교차이유통계학의의(P<0.05)；의서미탄조환자적혈청E2억제솔급유효억제솔우우기타량조(P<0.05)。3조균미출현엄중불량반응；재체중증가상래곡서조우위현저(P<0.05)。결론방향화매억제제가유효치료부과내분비질병，차약물내수성호。
Objective To explore the application value of aromatase inhibitor in gynecologic endocrine diseases. Meth-ods 90 patients with gynecologic endocrine diseases treated in our hospital from August 2010 to August 2012 were se-lected and respectively for exemestane (n=36),anastrozole (n=28) and letrozole (n=26) treatment,the curative effect of aromatase inhibitors,three groups of patients with serum estradiol inhibition condition and adverse reactions occur were observed. Results The total effective rate was 94.44%,92.86% and 92.31% respectively in exemestane group,anastro-zole group and letrozole group,there was no statistically significant difference (P>0.05).The serum E2 level in three groups of patients were significantly decreased after treatment,the difference was statistically significant compared with before treatment (P<0.05).The serum E2 inhibition rate and efficient inhibition in exemestane group patients were better than the other two groups (P<0.05).No serious adverse reaction occurred in 3 groups,on weight gain letrozole group was significant (P<0.05). Conclusion Aromatase inhibitors can effectively treat gynecological endocrine diseases,and drug tolerance.