CAJ | 학술논문

目的：检测类风湿关节炎(RA)患者血中血浆纤维蛋白原(FIB)、纤维蛋白降解产物(FDP)、D一二聚体(DD)水平，并探讨它们与RA疾病活动的关系。方法：2011年1月-2013年8月收治RA患者60例，其中活动性RA组30例，稳定性RA对照组30例。记录患者的临床和实验室指标，并研究其与RA患者疾病活动度(DAS28评分)、红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)等指标的关系。结果：活动性RA组D-二聚体、FIB、FDP均升高，与稳定性RA组比较差异有统计学意义(P＜0.01)。在RA患者中D-二聚体增高组DAS28水平高于D-二聚体正常组(P＜0.0l)。D-二聚体增高组RA患者的ESR、CRP和RF水平均高于D-二聚体水平正常组RA患者(P＜0.05)。结论：RA患者血中D-二聚体和FIB、FDP水平均有升高，且与疾病活动度密切相关。凝血-纤溶系统激活可能在RA的病情发展和病理过程中发挥作用。
목적：검측류풍습관절염(RA)환자혈중혈장섬유단백원(FIB)、섬유단백강해산물(FDP)、D일이취체(DD)수평，병탐토타문여RA질병활동적관계。방법：2011년1월-2013년8월수치RA환자60례，기중활동성RA조30례，은정성RA대조조30례。기록환자적림상화실험실지표，병연구기여RA환자질병활동도(DAS28평분)、홍세포침강솔(ESR)、C반응단백(CRP)、류풍습인자(RF)등지표적관계。결과：활동성RA조D-이취체、FIB、FDP균승고，여은정성RA조비교차이유통계학의의(P＜0.01)。재RA환자중D-이취체증고조DAS28수평고우D-이취체정상조(P＜0.0l)。D-이취체증고조RA환자적ESR、CRP화RF수평균고우D-이취체수평정상조RA환자(P＜0.05)。결론：RA환자혈중D-이취체화FIB、FDP수평균유승고，차여질병활동도밀절상관。응혈-섬용계통격활가능재RA적병정발전화병리과정중발휘작용。
Objective:To detecte the level of blood plasma fibrinogen(FIB),fibrin degradation products(FDP),D-two dimer (DD) in patients with rheumatoid arthritis(RA),and to explore their relationship with the disease activity of RA.Methods:60 cases with RA were selected from January 2011 to August 2013,in which 30 cases of activity as the RA group,30 cases of stability RA as the control group.Thrombotic diseases and tumor were excluded.All the patients were with no operation and trauma history in recent 6 months.Clinical and laboratory indexes were recorded,and study the relationship of its activity in patients with RA grade(DAS28 score),erythrocyte sedimentation rate(ESR),C reactive protein(CRP),rheumatoid factor(RF) and other indicators.Results:In the activity RA group D-two dimer,FIB,FDP were increased,and the differences were statistically significant compared with the stability RA group(P<0.01).The DAS28 levels in the two D-dimer increased group was higher than normal two D-dimer group(P<0.0l).In patients with RA,ESR,CRP and RF levels in two D-dimer increased group were higher than in normal two D-dimer group(P<0.05).Conclusion:The levels of D-two dimer and FIB,FDP in patients with RA were increased,and closely related to disease activity.Coagulation-fibrinolytic system may play a role in the progression of RA and pathological process activation.