重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
27期
3565-3566,3569
,共3页
方士强%孔德勇%梅芬%卢忠心
方士彊%孔德勇%梅芬%盧忠心
방사강%공덕용%매분%로충심
糖尿病2型%烟酰胺磷酸核糖基转移酶%瘦素%胰岛素%胰岛素抵抗
糖尿病2型%煙酰胺燐痠覈糖基轉移酶%瘦素%胰島素%胰島素牴抗
당뇨병2형%연선알린산핵당기전이매%수소%이도소%이도소저항
diabetes mellitus,type 2%nicotinamide phosphoribosy ltransferase%leptin%insulin
目的:探讨2型糖尿病(T2DM )患者血清中内脂素、瘦素及其他指标的表达水平、相关关系及临床意义。方法选取性别和年龄匹配的T2DM患者82例(T2DM组)和健康者71例(健康对照组),测定其血清内脂素、瘦素、胰岛素及血脂、血糖水平。结果 T2DM组的内脂素、瘦素、血清胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、空腹胰岛素(FINS)、稳态胰岛素抵抗指数(HOMA-IR)、2 h FPG、2 h FINS与健康对照组比较,差异有统计学意义(P<0.05)。相关性分析显示,T2DM 组中内脂素与体质量指数(BMI)、FINS、HOMA-IR、TC、TG、LDL-C均呈正相关(P<0.05),与HDL-C成负相关(P<0.05);瘦素与BMI、FINS、HOMA-IR成正相关(P<0.05)。结论 T2DM 患者血清中内脂素及瘦素的表达水平高于健康者,与血脂、血糖及胰岛素密切相关,可能成为T2DM新的诊断指标。
目的:探討2型糖尿病(T2DM )患者血清中內脂素、瘦素及其他指標的錶達水平、相關關繫及臨床意義。方法選取性彆和年齡匹配的T2DM患者82例(T2DM組)和健康者71例(健康對照組),測定其血清內脂素、瘦素、胰島素及血脂、血糖水平。結果 T2DM組的內脂素、瘦素、血清膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、空腹血糖(FPG)、空腹胰島素(FINS)、穩態胰島素牴抗指數(HOMA-IR)、2 h FPG、2 h FINS與健康對照組比較,差異有統計學意義(P<0.05)。相關性分析顯示,T2DM 組中內脂素與體質量指數(BMI)、FINS、HOMA-IR、TC、TG、LDL-C均呈正相關(P<0.05),與HDL-C成負相關(P<0.05);瘦素與BMI、FINS、HOMA-IR成正相關(P<0.05)。結論 T2DM 患者血清中內脂素及瘦素的錶達水平高于健康者,與血脂、血糖及胰島素密切相關,可能成為T2DM新的診斷指標。
목적:탐토2형당뇨병(T2DM )환자혈청중내지소、수소급기타지표적표체수평、상관관계급림상의의。방법선취성별화년령필배적T2DM환자82례(T2DM조)화건강자71례(건강대조조),측정기혈청내지소、수소、이도소급혈지、혈당수평。결과 T2DM조적내지소、수소、혈청담고순(TC)、삼선감유(TG)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、공복혈당(FPG)、공복이도소(FINS)、은태이도소저항지수(HOMA-IR)、2 h FPG、2 h FINS여건강대조조비교,차이유통계학의의(P<0.05)。상관성분석현시,T2DM 조중내지소여체질량지수(BMI)、FINS、HOMA-IR、TC、TG、LDL-C균정정상관(P<0.05),여HDL-C성부상관(P<0.05);수소여BMI、FINS、HOMA-IR성정상관(P<0.05)。결론 T2DM 환자혈청중내지소급수소적표체수평고우건강자,여혈지、혈당급이도소밀절상관,가능성위T2DM신적진단지표。
Objective To investigate the expression levels of serum visfatin ,leptin and other indexes and their correlation and clinical significance in the patients with type 2 diabetes mellitus(T2DM ) .Methods Eighty-two age-matched and gender-matched cases of T2DM (T2DM group)and 71 cases of healthy subjects(health control group)were tested serum visfatin ,leptin ,insulin ,lipid and glycemia levels .Results The serum visfatin ,leptin ,triglycerides(TG) ,total cholesterol(TC) ,high-density lipoprotein choles-terol(HDL-C) and low density lipoprotein cholesterol(LDC-C) ,fasting plasma glucose ,fasting insulin(FINS) ,homeostasis model assessment of insulin resistance(OMA-IR) ,2 h FPG ,2 h FINS had statistically significant differences between the T 2DM group and the health control group(P< 0 .05);the stepwise regression analysis showed that visfatin were positively correlated with BMI , FINS ,HOMA-IR ,TC ,TG ,LDL-C (P<0 .05)and negatively correlated with HDL-C(P<0 .05);leptin were positively correlated with BMI ,FINS ,HOMA-IR(P<0 .05) .Conclusion Serum visfatin and leptin in the T2DM patients are hither than those in the healthy subjects and closely related with blood lipid ,blood glucose and insulin ,which may become the new diagnostic indexes of T2DM .