CAJ | 학술논문

目的：观察甲泼尼龙联合丙种球蛋白治疗复发缓解型多发性硬化的疗效。方法：125例复发缓解型多发性硬化患者随机分为3组，甲泼尼龙（MPS）组40例，丙种球蛋白组（IG）组43例，甲泼尼龙联合丙种球蛋白（MPS+IG）组42例进行治疗。结果：MPS+IG组疗效明显优于MPS组和IG组，两组比较，差异具有统计学意义（P<0.05）。治疗后7d及15d，MPS+IG组EDSS评分较MPS 组和IG组明显减少（P<0.05），两组比较，差异具有统计学意义。MPS+IG组1年内复发率明显小于MPS 组及IG组（P<0.05），两组比较，差异具有统计学意义。结论：甲泼尼龙联合丙种球蛋白治疗复发缓解型多发性硬化疗效明显，能减少多发性硬化的复发。
목적：관찰갑발니룡연합병충구단백치료복발완해형다발성경화적료효。방법：125례복발완해형다발성경화환자수궤분위3조，갑발니룡（MPS）조40례，병충구단백조（IG）조43례，갑발니룡연합병충구단백（MPS+IG）조42례진행치료。결과：MPS+IG조료효명현우우MPS조화IG조，량조비교，차이구유통계학의의（P<0.05）。치료후7d급15d，MPS+IG조EDSS평분교MPS 조화IG조명현감소（P<0.05），량조비교，차이구유통계학의의。MPS+IG조1년내복발솔명현소우MPS 조급IG조（P<0.05），량조비교，차이구유통계학의의。결론：갑발니룡연합병충구단백치료복발완해형다발성경화료효명현，능감소다발성경화적복발。
Objective:To observe the effect of treatment of relapsing-remitting multiple sclerosis by methylprednisolone and immunoglobulin. Methods:125 relapsing-remitting multiple sclerosis patients were randomly divided into three groups(methylprednisolone(MPS) group 40 cases, immunoglobulin group(IG) 43 cases, methylprednisolone and immunoglobulin(MPS+IG) group 42 cases). The patients were treated in the three groups. Results:The effect in the MPS+IG group was significantly better than MPS group and IG group, comparing the two groups, the difference has statistical significance (P<0.05).EDSS score in the MPS+IG group was significantly lower than MPS group and IG group ,comparing the two groups, the difference has statistical significance (P<0.05). The The recurrence rate in the MPS+IG group was significantly less than MPS group and IG group, comparing the two groups, the difference has statistical significance (P<0.05). Conclusion:The treatment of relapsing-remitting multiple sclerosis by methylprednisolone and immunoglobulin had better effect and could reduce the recurrence of multiple sclerosis.