国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2013年
5期
535-537
,共3页
胡慧敏%王一卓%黄东生%张谊%张伟令%史季桐%马建民%赵军阳
鬍慧敏%王一卓%黃東生%張誼%張偉令%史季桐%馬建民%趙軍暘
호혜민%왕일탁%황동생%장의%장위령%사계동%마건민%조군양
神经元特异性烯醇化酶%视网膜母细胞瘤%病理
神經元特異性烯醇化酶%視網膜母細胞瘤%病理
신경원특이성희순화매%시망막모세포류%병리
Neuron specific enolase%Retinoblastoma%Pathology
目的 分析视网膜母细胞瘤患儿血清神经元特异性烯醇化酶(neuron-specific enolase,NSE)与临床分期的相关性.方法 收集2005年至2012年同仁医院213例经病理明确诊断为视网膜母细胞瘤的患儿临床资料,均为单眼发病.依据病理及全身检查,分为眼内期146例、眼外期48例及远处转移期19例.根据病理和年龄,将所有病例分为≤3岁的眼内期组、眼外期组、远处转移期组；＞3岁的眼内期组、眼外期组和远处转移期组.结果 眼内期组血清NSE水平为(27.5±10.8) μg/L,眼外期组血清NSE水平为(28.2±8.5)μg/L,远处转移期组血清NSE水平为(149.0±128.6)μg/L.≤3岁患儿各组NSE结果差异有统计学意义(P＜0.05).＞3岁患儿各组NSE结果差异有统计学意义(P＜0.05).远处转移期组患儿血清NSE水平明显高于眼内期组、眼外期组.结论 血清NSE值的测定对于视网膜母细胞瘤远处转移有诊断和鉴别诊断价值.
目的 分析視網膜母細胞瘤患兒血清神經元特異性烯醇化酶(neuron-specific enolase,NSE)與臨床分期的相關性.方法 收集2005年至2012年同仁醫院213例經病理明確診斷為視網膜母細胞瘤的患兒臨床資料,均為單眼髮病.依據病理及全身檢查,分為眼內期146例、眼外期48例及遠處轉移期19例.根據病理和年齡,將所有病例分為≤3歲的眼內期組、眼外期組、遠處轉移期組；＞3歲的眼內期組、眼外期組和遠處轉移期組.結果 眼內期組血清NSE水平為(27.5±10.8) μg/L,眼外期組血清NSE水平為(28.2±8.5)μg/L,遠處轉移期組血清NSE水平為(149.0±128.6)μg/L.≤3歲患兒各組NSE結果差異有統計學意義(P＜0.05).＞3歲患兒各組NSE結果差異有統計學意義(P＜0.05).遠處轉移期組患兒血清NSE水平明顯高于眼內期組、眼外期組.結論 血清NSE值的測定對于視網膜母細胞瘤遠處轉移有診斷和鑒彆診斷價值.
목적 분석시망막모세포류환인혈청신경원특이성희순화매(neuron-specific enolase,NSE)여림상분기적상관성.방법 수집2005년지2012년동인의원213례경병리명학진단위시망막모세포류적환인림상자료,균위단안발병.의거병리급전신검사,분위안내기146례、안외기48례급원처전이기19례.근거병리화년령,장소유병례분위≤3세적안내기조、안외기조、원처전이기조；＞3세적안내기조、안외기조화원처전이기조.결과 안내기조혈청NSE수평위(27.5±10.8) μg/L,안외기조혈청NSE수평위(28.2±8.5)μg/L,원처전이기조혈청NSE수평위(149.0±128.6)μg/L.≤3세환인각조NSE결과차이유통계학의의(P＜0.05).＞3세환인각조NSE결과차이유통계학의의(P＜0.05).원처전이기조환인혈청NSE수평명현고우안내기조、안외기조.결론 혈청NSE치적측정대우시망막모세포류원처전이유진단화감별진단개치.
Objective To analyze correlation between serum neuron specific enolase(NSE) and clinical stages of retinoblastoma in children.Methods Clinical data of 213 unilateral retinoblastoma cases were collected in Tongren hospital from 2005 to 2012.These cases were clearly diagnosed by pathology.According to the pathology and systemic examination,these cases were divided into intraocular stage(146 cases),extraocular stage(48 cases) and distant metastasis period(19 cases).Results The serum NSE level of intraocular stage group was (27.5 ± 10.8) μg/L,the serum NSE level of extraocular stage group was (28.2 ± 8.5) μg/L,the serum NSE level of distant metastasis period group was (149.0 ± 128.6) μg/L.According to the pathology and age,all patients were divided into age less than 3 years of intraocular stage group,extraocular stage group and distant metastasis period group,more than 3 years of intraocular group,extraocular stage group and distant metastasis period group.The difference of serum NSE levels in three groups were compared by analysis of variance.The difference of NSE level was statistically significant in three groups who were less than 3 years(P ＜0.05).The results of three groups.The difference of NSE level was statistically significant in three groups who were more than 3 years(P ＜0.05).The serum NSE level of distant metastasis period group was significantly higher than those of intraocular stage group and extraocular stage group.Conclusion The detection of serum NSE was valuable in diagnosis and differential diagnosis of retinoblastoma metastasis period.
