CAJ | 학술논문

目的：研究分析对急性期精神病患者采用奥氮平治疗的效果。方法本研究于2012年6月~2014年1月开展，入选研究的对象均为该阶段在本院接受治疗的急性期精神病患者，共120例，根据患者治疗期间接受的不同治疗方案，将其分为两组，对照组60例，临床期间采用氯氮平治疗，观察组60例，临床期间采用奥氮平治疗，比较两组患者的治疗效果，并评估其治疗前后的BPRS评分、PANSS评分、TESS评分水平情况。结果经临床治疗，观察组患者的临床有效率为76.7%，对照组为66.7%，组间比较差异明显，具有统计学意义，P＜0.05；治疗后两组患者的BPRS评分均有明显降低，与治疗前比较差异明显，P＜0.05，且观察组患者的评分水平低于对照组，组间比较差异具有统计学意义，P＜0.05；治疗后两组患者的 PANSS评分均有明显下降，与治疗前比较，P＜0.05，且观察组患者的下降水平优于对照组，P＜0.05，经TESS不良反应症状量表评估两组患者的不良反应情况，两组无明显差异，P＞0.05。结论对急性期精神病患者采用奥氮平治疗可显著改善患者的精神病症状，且无明显不良反应，值得临床重视和广泛推广。
목적：연구분석대급성기정신병환자채용오담평치료적효과。방법본연구우2012년6월~2014년1월개전，입선연구적대상균위해계단재본원접수치료적급성기정신병환자，공120례，근거환자치료기간접수적불동치료방안，장기분위량조，대조조60례，림상기간채용록담평치료，관찰조60례，림상기간채용오담평치료，비교량조환자적치료효과，병평고기치료전후적BPRS평분、PANSS평분、TESS평분수평정황。결과경림상치료，관찰조환자적림상유효솔위76.7%，대조조위66.7%，조간비교차이명현，구유통계학의의，P＜0.05；치료후량조환자적BPRS평분균유명현강저，여치료전비교차이명현，P＜0.05，차관찰조환자적평분수평저우대조조，조간비교차이구유통계학의의，P＜0.05；치료후량조환자적 PANSS평분균유명현하강，여치료전비교，P＜0.05，차관찰조환자적하강수평우우대조조，P＜0.05，경TESS불량반응증상량표평고량조환자적불량반응정황，량조무명현차이，P＞0.05。결론대급성기정신병환자채용오담평치료가현저개선환자적정신병증상，차무명현불량반응，치득림상중시화엄범추엄。
Objective Research and Analysis treatment ef ect on the patients of acute psychosis with olanzapine.Methods 120 patients were selected for the stage of acute phase treatment in our hospital from June 2012 to January 2014,they were divided into two groups according to the dif erent treatment options. 60 cases in the control group were with treatment of clozapine of the clinical period, and the observation group, 60 cases, with olanzapine. Therapeutic ef ects of two groups were compared before and after treatment, and to evaluate the BPRS,PANSS,TESS scores.Results After treatment,the ef ective rate of observation group was 76.7%, and 66.7%in the control group.The dif erences between the two groups had the statistical significance(P<0.05). After treatment,the patient's BPRS scores were significantly lower,with significant dif erences between pre-treatment (P<0.05), and the degree of decline in patients in the observation group was greater than the control group (P<0.05). By TESS scale assessment of adverse reactions in patients of two groups, there was no significant dif erence between them(P>0.05).Conclusion Olanzapine can significantly improve the patient's psychiatric symptoms in patients with acute psychosis, and no significant adverse reactions, which has good security, and is worthy of at ention and widely promoted.