CAJ | 학술논문

目的：用免疫组织化学的方法检测乳腺浸润性导管癌特定蛋白的表达并进行免疫分型，探讨不同的免疫分型与病理特征的关系。方法用 EnVision二步法检测98例乳腺浸润性导管癌ER、PR、HER-2和CK5/6，根据结果进行免疫分型。结果98例乳腺浸润性导管癌 ER、PR、HER-2和 CK5/6的阳性病例为64例、45例、24例、23例。免疫分型：管腔 A型54例、管腔 B型20例、HER-2过表达型7例、基底细胞样型9例和无法分类型8例。病理特征指标为肿块大小、组织学分级和淋巴结转移，免疫分型与组织学分级的差异具有统计学意义（P<0.05）。免疫分型与肿块大小、淋巴结转移的差异具无统计学意义（P>0.05）。结论用免疫组织化学方法对乳腺浸润性导管癌进行免疫分型，方法简便可行，对于评估预后和指导临床治疗具有一定的意义。
목적：용면역조직화학적방법검측유선침윤성도관암특정단백적표체병진행면역분형，탐토불동적면역분형여병리특정적관계。방법용 EnVision이보법검측98례유선침윤성도관암ER、PR、HER-2화CK5/6，근거결과진행면역분형。결과98례유선침윤성도관암 ER、PR、HER-2화 CK5/6적양성병례위64례、45례、24례、23례。면역분형：관강 A형54례、관강 B형20례、HER-2과표체형7례、기저세포양형9례화무법분류형8례。병리특정지표위종괴대소、조직학분급화림파결전이，면역분형여조직학분급적차이구유통계학의의（P<0.05）。면역분형여종괴대소、림파결전이적차이구무통계학의의（P>0.05）。결론용면역조직화학방법대유선침윤성도관암진행면역분형，방법간편가행，대우평고예후화지도림상치료구유일정적의의。
Objective This study try to subclassify breast cancer into dif edrnt subgroups according to immunohistochemical stain.The relationship between subtypes and pathological cariticrisetic have been disscused.Methods Nighty-eight cases of infiltrative ductal carcinoma were studied using immunohistochemical staining with the antibody panel of ER,PR,HER 2 and CK5/6.The immunological subclasify is made according to the immunohistochemical stain.and previous reports. Results The expression of ER,PR, HER-2 and CK5/6 were det ected in 65.31%,45.92%,24.49%and 23.47%. Al cases were immunoclassified into five groups, with luminal A (54 cases), luminal B (20 cases),HER-2 positive (7 cases),balal-like (9 cases)and unclassied cases (8 cases). There are statistical significant in the dif erence between immunohistochemical subtypes and histocytical groups. No statistical significant have been found between immunohistochemical subtypes and other pathological features. Conclusion Acconding to immunohistochemical stain,the infiltrative ductal carcinoma could be subclassified into five subgrtypes.There is a role in evaluating the profnosis and guiding the clinical treatment.