CAJ | 학술논문

目的：探讨耳后注射甲强龙对难治性突发性聋的治疗效果。方法45例经全身糖皮质激素治疗后未痊愈的全部频率下降的突发性聋患者，随机分为两组：对照组(23例)仅给予降低纤维蛋白原、改善微循环及营养神经等常规治疗，耳后组（22例）在此治疗基础上给予耳后注射甲泼尼龙琥珀酸钠20mg，隔日1次，共3次。结果给药后两周：耳后组及对照组总有效率分比为50%（11/22），30.4%(7/23)；显效率分别为22.7%（5/22），0。耳后组气导平均听阈提高20.01±14.11dB，对照组提高10.47±8.53dB，两组之间有显著差异（P=0.0087）；耳后组低频（250Hz，500Hz）气导平均听阈提高更显著，分别提高24.09±16.95dB；25.23±18.29dB；而对照组低频（250Hz，500Hz）分别提高10.43±9.87dB；11.52±9.46dB；两组之间有显著差异（P=0.0018，P=0.0027）。结论耳后注射甲强龙治疗难治性突发性聋，疗效显著，且对低频听力提高的效果更佳。
목적：탐토이후주사갑강룡대난치성돌발성롱적치료효과。방법45례경전신당피질격소치료후미전유적전부빈솔하강적돌발성롱환자，수궤분위량조：대조조(23례)부급여강저섬유단백원、개선미순배급영양신경등상규치료，이후조（22례）재차치료기출상급여이후주사갑발니룡호박산납20mg，격일1차，공3차。결과급약후량주：이후조급대조조총유효솔분비위50%（11/22），30.4%(7/23)；현효솔분별위22.7%（5/22），0。이후조기도평균은역제고20.01±14.11dB，대조조제고10.47±8.53dB，량조지간유현저차이（P=0.0087）；이후조저빈（250Hz，500Hz）기도평균은역제고경현저，분별제고24.09±16.95dB；25.23±18.29dB；이대조조저빈（250Hz，500Hz）분별제고10.43±9.87dB；11.52±9.46dB；량조지간유현저차이（P=0.0018，P=0.0027）。결론이후주사갑강룡치료난치성돌발성롱，료효현저，차대저빈은력제고적효과경가。
Objective To assess the efficacy of postauricular injection of methylprednisolone in treating refractory sud-den hearing loss. Methods Forty five cases of sudden hearing loss that failed systematic glucocorticoids therapy were includ-ed in this study and divided into two groups. The Control group (n=23) was given only conventional treatment. The postauricu-lar injection group (n=22) received 3 doses of postauricular injection of methylprednisolone at 20 mg qd. in addition to con-ventional treatments. Results At 2 weeks after treatment, the rates of complete recovery and significant improvement were 50%(11/22) and 22.7%(5/22) in the postauricular injection group, and 30.4%(7/23)and 0 in the control group, respectively. Pure tone audiometry at all frequencies improved by 20.01±14.11 dB on average in the postauricular group, and 10.47±8.53 dB in the control group. The difference was statistically significant (P=0.0087). The PTA at 250 Hz and 500 Hz improved by 24.09±16.95 dB and 25.23±18.29 dB in the postauricular injection group, and 10.43±9.87 dB and 11.52±9.46 dB in the con-trol group. The difference again was statistically significant (P=0.0018, P=0.0027). Conclusion Postauricular methylprednis-olone injection is an effective therapy for refractory sudden hearing loss, especially for low-frequency involvement.