中国中西医结合外科杂志
中國中西醫結閤外科雜誌
중국중서의결합외과잡지
CHINESE JOURNAL OF SURGERY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2014年
5期
488-493
,共6页
rs7574865位点%STAT4基因%基因多态性%类风湿关节炎%Meta分析
rs7574865位點%STAT4基因%基因多態性%類風濕關節炎%Meta分析
rs7574865위점%STAT4기인%기인다태성%류풍습관절염%Meta분석
Rheumatoid arthritis%STAT4 transcription factor%polymorphism%meta-analysis
目的：综合评价信息传导与转录激活因子-4基因（STAT4基因）rs7574865位点单核苷酸多态性与类风湿关节炎易感性的相关性。方法：计算机检索Pubmed、Embase、中国生物医学文献数据库和万方数据库数据库等，并手工检索相关杂志，收集有关不同人群STAT4基因rs7574865位点单核苷酸多态性的等位基因频率、基因型频率与类风湿性关节炎易感性相关性的研究，采用Stata 12.0软件进行Meta分析；选择的遗传模型包括GT+TT与GG比较，TT与GT+GG比较，TT与GG比较以及等位基因T与G之间比较。结果：STAT4基因rs7574865位点T等位基因频率与类风湿性关节炎易感性可能具有相关性(OR=1.259,95%CI=1.202-1.319, P＜0.001)；T等位基因频率与类风湿性关节炎易感性的相关性在欧洲、亚洲、非洲、拉丁美洲人群中有统计学意义；在总体人口中STAT4基因rs7574865位点的基因型与类风湿性关节炎易感性可能具有相关性；在总体人口中STAT4基因rs7574865位点多态性与抗CCP抗体阳性或RF因子阳性类风湿性关节炎易感性仍可能具有相关性。结论：STAT4基因rs7574865位点单核苷酸多态性与类风湿性关节炎易感性可能具有相关性，而且这种相关性可能独立于患者RF因子以及抗CCP抗体水平。
目的：綜閤評價信息傳導與轉錄激活因子-4基因（STAT4基因）rs7574865位點單覈苷痠多態性與類風濕關節炎易感性的相關性。方法：計算機檢索Pubmed、Embase、中國生物醫學文獻數據庫和萬方數據庫數據庫等，併手工檢索相關雜誌，收集有關不同人群STAT4基因rs7574865位點單覈苷痠多態性的等位基因頻率、基因型頻率與類風濕性關節炎易感性相關性的研究，採用Stata 12.0軟件進行Meta分析；選擇的遺傳模型包括GT+TT與GG比較，TT與GT+GG比較，TT與GG比較以及等位基因T與G之間比較。結果：STAT4基因rs7574865位點T等位基因頻率與類風濕性關節炎易感性可能具有相關性(OR=1.259,95%CI=1.202-1.319, P＜0.001)；T等位基因頻率與類風濕性關節炎易感性的相關性在歐洲、亞洲、非洲、拉丁美洲人群中有統計學意義；在總體人口中STAT4基因rs7574865位點的基因型與類風濕性關節炎易感性可能具有相關性；在總體人口中STAT4基因rs7574865位點多態性與抗CCP抗體暘性或RF因子暘性類風濕性關節炎易感性仍可能具有相關性。結論：STAT4基因rs7574865位點單覈苷痠多態性與類風濕性關節炎易感性可能具有相關性，而且這種相關性可能獨立于患者RF因子以及抗CCP抗體水平。
목적：종합평개신식전도여전록격활인자-4기인（STAT4기인）rs7574865위점단핵감산다태성여류풍습관절염역감성적상관성。방법：계산궤검색Pubmed、Embase、중국생물의학문헌수거고화만방수거고수거고등，병수공검색상관잡지，수집유관불동인군STAT4기인rs7574865위점단핵감산다태성적등위기인빈솔、기인형빈솔여류풍습성관절염역감성상관성적연구，채용Stata 12.0연건진행Meta분석；선택적유전모형포괄GT+TT여GG비교，TT여GT+GG비교，TT여GG비교이급등위기인T여G지간비교。결과：STAT4기인rs7574865위점T등위기인빈솔여류풍습성관절염역감성가능구유상관성(OR=1.259,95%CI=1.202-1.319, P＜0.001)；T등위기인빈솔여류풍습성관절염역감성적상관성재구주、아주、비주、랍정미주인군중유통계학의의；재총체인구중STAT4기인rs7574865위점적기인형여류풍습성관절염역감성가능구유상관성；재총체인구중STAT4기인rs7574865위점다태성여항CCP항체양성혹RF인자양성류풍습성관절염역감성잉가능구유상관성。결론：STAT4기인rs7574865위점단핵감산다태성여류풍습성관절염역감성가능구유상관성，이차저충상관성가능독립우환자RF인자이급항CCP항체수평。
Objective Many genetic studies have suggested an association of rs7574865 polymorphism of STAT4 gene and Rheumatoid arthritis (RA), but evidence remains conflicting. To investigate whether combined evidence to show the association between polymorphism in signal transducers and activators of transcription 4 (STAT4) gene rs7574865 polymorphism and RA. Methods A systematic search of all relevant studies pub-lished through Mar 2013 was conducted using the MEDLINE, EMBASE, OVID, and ScienceDirect. Seventeen case-control studies with a total of 28 comparisons (25300 RA patients and 26326 controls) met the inclusion criteria. Meta-analysis was conducted for genotype TT versus GT+GG (recessive model), GT+TT versus GG (dom-inant model), TT versus GG (codominant model) and T-allele. Results Meta-analysis showed an association between RA and the STAT4 rs7574865 TT genotype (OR = 1.430, 95%CI = 1.299-1.574, P<0.001), GT+TT genotype (OR = 1.352, 95%CI = 1.243-1.471, P<0.001) and T-allele (OR = 1.259, 95%CI = 1.202-1.319, P<0.001) in all subjects. Stratification of RA patients according to ethnic groups demonstrated that TT geno-type, GT+TT genotype and T-allele were found to be significantly associated with RA in Europeans, Asians, Afri-cans and Latin Americans. Subgroup analysis according to absence or presence of rheumatoid factor (RF)/anti-cy-clic citrullinated peptide (anti-CCP) positive or negative revealed that the association between rs7574865 poly-morphism of STAT4 gene and RA might be independent of the presence of RF and CCP antibodies. Conclusion This demonstrates that STAT4 rs7574865 polymorphism may confer susceptibility to RA. The association may not be dependent of the presence of RF and CCP antibodies. Because of the limited number of studies available in Africans and Latin Americans, further studies with large sample size are required.
