CAJ | 학술논문

提出人类抗病毒感染的“RNAi自限假说”：在反转录酶和整合酶介导下，部分侵染病毒的mRNA被人类或其他动物宿主随机反转录成cDNA分子，并整合进宿主基因组中，形成能够抑制同种病毒增殖的免疫RNA（imRNA）分子。 imRNA激活宿主的小RNA依赖性的防御机制，抑制病毒在宿主体内的繁殖扩增，使被感染宿主与侵染病毒之间达成一种“病毒持续低水平存在而宿主无明显病征”的潜伏感染状态。本研究进一步从“人类基因组中反转录酶基因和整合酶基因类似功能序列的存在性”、“人类基因组中病毒基因组片段的存在性”，以及“病毒感染动物模型”三方面，初步论证假说的科学性，并简述假说在“病毒病流行趋势预测”方面的应用。上述假说与中医理论精神交融，应用中药干预病毒与宿主的互作程序，促使二者建立和谐共处的潜伏感染状态，而非直接抑杀病毒，应是研发抗病毒中药新药的新思路。
제출인류항병독감염적“RNAi자한가설”：재반전록매화정합매개도하，부분침염병독적mRNA피인류혹기타동물숙주수궤반전록성cDNA분자，병정합진숙주기인조중，형성능구억제동충병독증식적면역RNA（imRNA）분자。 imRNA격활숙주적소RNA의뢰성적방어궤제，억제병독재숙주체내적번식확증，사피감염숙주여침염병독지간체성일충“병독지속저수평존재이숙주무명현병정”적잠복감염상태。본연구진일보종“인류기인조중반전록매기인화정합매기인유사공능서렬적존재성”、“인류기인조중병독기인조편단적존재성”，이급“병독감염동물모형”삼방면，초보론증가설적과학성，병간술가설재“병독병류행추세예측”방면적응용。상술가설여중의이론정신교융，응용중약간예병독여숙주적호작정서，촉사이자건립화해공처적잠복감염상태，이비직접억살병독，응시연발항병독중약신약적신사로。
A new hypothesis for human anti-virus infection,named RNAi self-limiting hypothesis,is proposed in the paper. In the endogenous reverse transcriptase and integrase mediated ,viral mRNAs are randomly re-verse transcribed into cDNAs in host cell,some of which are integrated into human genome,and further transcribed into an immunospecific RNA(imRNA) with the function of inhibiting of the same viral multipli-cation in infected cells by the RNA interference mechanism. imRNA activates host small RNA-dependent defense mechanisms to suppress the viral multiplication,and establish a latent infection state between virus and host,which host remains persistently viral infection at low level without obvious signs of disease. This hypothesis is initially tested from three aspects of the existence of the reverse transcriptase-like and inte-grase-like genes in human genome,the existence of viral homologous sequences in human genome,and virus-infected animal model. Furthermore,implication of hypothesis in forecasting viral disease epidemic trend is briefly discussed in the paper. The hypothesis was spiritual communion with the traditional Chinese medicine theory “balance”. Establishing a harmonious coexistence of latent infection between virus and host by intervening their interaction program with Chinese medicinal,rather than killing virus directly,should be a new idea on research and development of antiviral medicine.