CAJ | 학술논문

探讨姜黄素对镉染毒小鼠急性肝脏损伤的保护作用及其可能机制．构建镉致小鼠肝脏损伤模型，同时给予姜黄素保护，通过测定抗氧化酶超氧化歧化酶（SOD ）和过氧化氢酶（CAT）；氧化损伤指标蛋白羰基化（PCO）、一氧化氮（NO）含量，以及肝脏内微量元素Cd2＋、Z n2＋和C u2＋的含量，研究镉对肝脏的损伤程度以及姜黄素的保护效果．姜黄素降低肝脏内NO、PCO的含量，缓解SOD、CAT活性降低（p＜0．05），减少Zn2＋、Cu2＋流失．姜黄素通过拮抗镉染毒所致的氧化应激反应，对肝脏的损伤起到保护作用．
탐토강황소대력염독소서급성간장손상적보호작용급기가능궤제．구건력치소서간장손상모형，동시급여강황소보호，통과측정항양화매초양화기화매（SOD ）화과양화경매（CAT）；양화손상지표단백탄기화（PCO）、일양화담（NO）함량，이급간장내미량원소Cd2＋、Z n2＋화C u2＋적함량，연구력대간장적손상정도이급강황소적보호효과．강황소강저간장내NO、PCO적함량，완해SOD、CAT활성강저（p＜0．05），감소Zn2＋、Cu2＋류실．강황소통과길항력염독소치적양화응격반응，대간장적손상기도보호작용．
Exploring the protection of curcumin on acute liver injury in mice exposed to cadmi-um and its possible mechanism .Liver injury induced by cadmium in mice was established , given curcumin protection at the same time ,through detect the content of antioxidant en-zymes superoxide dismutase (SOD) and catalase (CAT);oxidative damage of protein carbon-yl (PCO) ,nitric oxide (NO) ,and trace elements Cd ,Cu and Zn contentin the liver ,to re-search of cadmium on the liver damage degree and the protective effect of curcumin .Curcu-min can reduce liver injury caused by cadmium ,mainly by reducing the content of NO and PCO(p<0 .05) ,respite the activity of SOD、CAT ,reducing the cost of Zn2+ ,Cu2+ .Curcu-min though antagonism oxidative stress induce cadmium exposure ,have a protective effect on the liver injury .