CAJ | 학술논문

目的：探讨扶正消积汤联合FOLFOX方案治疗中晚期结肠癌的疗效。方法将140例中晚期结肠癌患者按随机数字表法分为观察组（70例）与对照组（70例）。观察组患者接受扶正消积汤联合FOLFOX方案治疗，对照组患者仅接受FOLFOX方案治疗。2个化疗周期后进行疗效评价。结果①2组患者近期疗效相比差异无统计学意义（ P＞0．05）。②治疗前，2组患者CD4＋T细胞、CD8＋T细胞、CD4＋／CD8＋比值、白细胞计数（ WBC）、红细胞计数（ RBC）、红细胞压积（HCT）、血红蛋白浓度（Hb）相比差异无统计学意义（P＞0．05）。治疗后，观察组上述指标均显著高于对照组（P＜0．05）。结论扶正消积汤联合FOLFOX方案治疗中晚期结肠癌的效果确切，还具有改善患者免疫功能、降低化疗引起的骨髓抑制等特点。
목적：탐토부정소적탕연합FOLFOX방안치료중만기결장암적료효。방법장140례중만기결장암환자안수궤수자표법분위관찰조（70례）여대조조（70례）。관찰조환자접수부정소적탕연합FOLFOX방안치료，대조조환자부접수FOLFOX방안치료。2개화료주기후진행료효평개。결과①2조환자근기료효상비차이무통계학의의（ P＞0．05）。②치료전，2조환자CD4＋T세포、CD8＋T세포、CD4＋／CD8＋비치、백세포계수（ WBC）、홍세포계수（ RBC）、홍세포압적（HCT）、혈홍단백농도（Hb）상비차이무통계학의의（P＞0．05）。치료후，관찰조상술지표균현저고우대조조（P＜0．05）。결론부정소적탕연합FOLFOX방안치료중만기결장암적효과학절，환구유개선환자면역공능、강저화료인기적골수억제등특점。
Objective To investigate the therapeutic efficacy of Fuzheng Xiaoji decoction plus FOLFOX in the treatment of advanced colon cancer .Methods 140 cases of advanced colon cancer were divided into the observation group (70 cases) and the control group(70 cases) according to random number table method ,and the former received Fuzheng Xiaoji decoction plus FOLFOX,while the latter was given FOLFOX .The therapeutic efficacy was evaluated after 2 cycles of chemotherapy .Results ①No significant difference was found in the short-term efficacy between the 2 groups(P>0.05).②Before treatment,no significant differences were found in the CD4 +T cells,CD8 +T cells,CD4 +/CD8 +ratio,white blood cells(WBC),red blood cells(RBC), hematocrit(HCT) and hemoglobin(Hb) between the 2 groups(P>0.05),while these before-mentioned indexes in the observa-tion group were significantly higher than those in the control group after treatment (P<0.05).Conclusion The Fuzheng Xiaoji decoction plus FOLFOX in the treatment of advanced colon cancer shows good therapeutic efficacy .Moreover , this scheme strengthens immune system and reduce bone marrow inhibition .